The aim of this study is to determine whether the presence and the extent of periodontitis are independently related to the presence and extent of coronary calcification.To determine if periodontal treatment has an positive effect on the…
ID
Source
Brief title
Condition
- Other condition
- Coronary artery disorders
- Bacterial infectious disorders
Synonym
Health condition
parodontale aandoeningen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Inflammatory burden of periodontal disease will be quantified with the
Periodontal Inflamed Surface Area (PISA) score.The endothelial function will be
measured employing *EndoScore* using the ENDOPAT.
Secondary outcome
Reynolds risk score
Framingham risk score
Questionnaires:
• Age
• Sex
• Ethnicity
• Socio-economic status
• Medical history and medication (history)
• Parental history
• Life-style (smoking, alcohol, drugs, stress)
• Oral hygiene
Physical examination:
• Blood Pressure (BP)
• Heart Rate (HR)
• Body Mass Index (BMI)
• Waist to Hip Ratio (WHR)
• Electrocardiogram (ECG)
Biochemical parameters:
• High sensitive C-reactive Protein (hsCRP)
• Total cholesterol
• High Density Lipoprotein (HDL) cholesterol
• Low Density Lipoprotein (LDL) cholesterol
• Triglycerides
• Estimated Glomerular Filtration Rate (eGFR)
• Glycated Hemoglobine (HbA1c)
Extra parameters for coupled studies:
One blood sample for DNA analysis of risk genes for both periodontitis and
coronary heart disease.
Oral rinse sample for microbiological analysis of the oral microbiome peformed
by pyrosequencing of 16Smicrobial DNA.
Background summary
Periodontitis is a chronic multi-causal inflammatory disease of the supportive
tissues of the teeth with progressive loss of attachment and alveolar bone.
Atherosclerosis is perceived today as a chronic inflammatory condition, and
infectious diseases are believed to contribute to its pathophysiology. In
recent years remarkable pathological and epidemiological relationships between
periodontitis and atherosclerosis have been presented. Many previous studies
use surrogate biomarkers in order to demonstrate the association between
periodontitis and coronary atherosclerosis. Unfortunately, more definitive
cardiovascular parameters and endpoints are still lacking.
Study objective
The aim of this study is to determine whether the presence and the extent of
periodontitis are independently related to the presence and extent of coronary
calcification.
To determine if periodontal treatment has an positive effect on the
cadiovacular paramaters.
Study design
Follow-up treatment study
Study burden and risks
The radiation exposure of a standard dental panoramic radiograph is estimated
to be 0.010 mSv, comparable to 1 day background exposure to the natural
radiation in The Netherlands.
Meibergdreef 9
Amsterdam 1105 AZ
NL
Meibergdreef 9
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
Age 45-70 years
Male and Female
All ethnicities
>= 10 teeth
Exclusion criteria
Edentulous
Known cardiovascular diseases
Known Diabetes Mellitus
Known autoimmune disorders
Known immunosuppressive disorders
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL43083.075.13 |