To investigate whether children with a history of Kawasaki disease have an increased IMT and arterial stifness compared to their healthy siblings.
ID
Source
Brief title
Condition
- Coronary artery disorders
- Arteriosclerosis, stenosis, vascular insufficiency and necrosis
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- IMT of the right and left carotid artery (communis, bulb and internal artery).
- Arterial stiffness of the left and right carotid artery.
Secondary outcome
None
Background summary
Kawasaki disease is a generalised vasculitis of the small and medium arteries.
The illness manifests as a febrile illness in young children, mostly under 5
years of age. The most prominent complication is the occurrence of coronary
aneurysms. Kawasaki disease is the most common cause of acquired heart disease
in children.
Patients with persisting aneurysms have an increased risk for myocardial
perfusion disorders, myocardial infarction and acute cardiac death because of
progressive stenosis and thrombosis of the aneurysm.
At this moment there is insufficient knowledge about the long term effects of
Kawasaki disease, especially for children without coronary aneurysms. Previous
histopathological and functional studies (coronary flow reserve, endothelial
function, arterial stiffness) show signs of an increased cardiovascular risk
pattern, even though these studies are not definite.
The Intima Media Thickness (IMT) is the thickness of the inner two layers
(intima-media) of an artery. It can be measured using ultrasound (B-Mode). IMT
is a validated method to evaluate the cardiovascular risk. During the same
ultrasound the distensibility of the artery is measured; a marker for arterial
stiffness.
Since 2002 IMT measurements are done in children visiting the Kawasaki
outpatient clinic in the AMC.
With this study we want to compare the IMT of children after Kawasaki disease
with healthy controls to evaluate whether there is a increased IMT and
stiffness (and a possible increased cardiovascular risk).
Study objective
To investigate whether children with a history of Kawasaki disease have an
increased IMT and arterial stifness compared to their healthy siblings.
Study design
Prospective, longitudinal.
Study burden and risks
There are no risks involved in the ultrasound examination. This examination is
safe, has no radiation, is pain free and does not have side effects.
A disadvantage of the study is a visit to the AMC. The burden of the actual
examination includes lying still for about 20 minutes.
Meibergdreef 9
Amsterdam 1105 AZ
NL
Meibergdreef 9
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
- Age between 7 and 30
- First degree relative with a history of Kawasaki disease
Exclusion criteria
- A history of Kawasaki disease
- A known history of cardiac illness or other (chronic) disease.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL46804.018.13 |