In the proposed study, we will experimentally elucidate the effect of DBS on various critical dimensions of cognitive control including: the free will experience, instrumental learning, environmental change detection and working memory.
ID
Source
Brief title
Condition
- Cognitive and attention disorders and disturbances
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Changes in the neural correlates related to specific aspects of cognitive
control.
Secondary outcome
Find what is common and different in the cognitive control network among a
number of other compulsive disorders.
Background summary
'Cognitive control' refers to a set of skills that allow us to flexibly adapt
our behavior in the context of our external environment and internal goals.
This ability is central to our notions of consciousness, agency, and will.
Moreover, functions critical in our daily life such as environmental change
detection, instrumental learning and attention/ working memory depend
critically on control processes. The loss of cognitive control is a major
component of many neuropsychiatric diseases, such as OCD. It has been reported
that OCD patients are likely to experience *an important loss of freedom*, in
their everyday lives (DSM IV).
Deep Brain Stimulation (DBS) of the Nucleus Accumbens (NAcc) treatment has been
found to be a very promising experimental option for certain groups of
treatment refractory OCD patients (Denys et al., 2010). This treatment involves
chronically stimulating the NAcc with the goal of modulating aberrant brain
activity, often resulting in substantial symptom improvement. Although the
stimulation is believed to modulate brain areas involved in cognitive control,
there has yet to be any investigation on how DBS influences any aspects of
cognitive control.
Study objective
In the proposed study, we will experimentally elucidate the effect of DBS on
various critical dimensions of cognitive control including: the free will
experience, instrumental learning, environmental change detection and working
memory.
Study design
Observational study without invasive measurements.
Study burden and risks
The risk associated with participation can be considered negligible and the
burden can be considered minimal.
Meibergdreef 5
Amsterdam 1105 AZ
NL
Meibergdreef 5
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
The presence of a primary diagnosis for OCD and treated with NAcc DBS. To be tested against healthy controls, and those diagnosed with OCD, misophonia, ADHD, and BDD.
Exclusion criteria
Abnormal hearing or (uncorrected) vision.
History of neurological/endocrine treatment or current neurological/endocrine treatment.
Average use of more than 3 alcoholic beverages daily.
Use of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement.
Irregular sleep/wake rhythm
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL44841.018.13 |