To investigate whether the peripheral nervous system is involved in paroxysmal neurological conditions.
ID
Source
Brief title
Condition
- Neurological disorders congenital
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
EMG measures
Secondary outcome
Concentration of Na, K, Mg, Ca in blood
Background summary
Some paroxysmal neurological conditions are caused by alterations of
ionchannels of the peripheral and central nervous system.
So far, little is known about the effects that such conditions have on the
peripheral nervous system. With surface EMG (electromyography), it can be
investigated whether the peripheral nervous system is also altered in
paroxysmal neurological conditions.
Study objective
To investigate whether the peripheral nervous system is involved in paroxysmal
neurological conditions.
Study design
Cross-sectional case-control study
Study burden and risks
EMG is a non-invasive technique that can lead to mild discomfort in some cases.
Blood withdrawal via venipuncture in the elbow has a very low rate of adverse
events. The needle puncture may cause bruising and in very rare cases an
infection of the skin or blood vessel may occur at the puncture site.
Achterweg 5
Heemstede 2103SW
NL
Achterweg 5
Heemstede 2103SW
NL
Listed location countries
Age
Inclusion criteria
good general health
18 y or older
normal cognitive functioning
speaking dutch
Exclusion criteria
use of medication with known effect on ion channel function
history of neuropathy or motor neuron disease
diabetes mellitus
pregnancy
any neurological disorder (healthy controls)
psychiatric disorder requiring treatment by psychiatrist
1st degree family member with epilepsy
Design
Recruitment
metc-ldd@lumc.nl
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL48452.058.14 |