In this pilot study we aim to investigate the additional value of sEMG signals of respiratory muscles during ICU admission in adults.
ID
Source
Brief title
Condition
- Neuromuscular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
* Feasibility
* Correlation of transcutaneous sEMG of the diaphragm with EAdi signal of
NAVA catheter.
* Correlation of transcutaneous sEMG of the diaphragm with airway pressure and
flow to detect patient * ventilator dyssynchrony
* Changes in sEMG signals during increased physical activity
* Correlation of sEMG fatigue parameters with clinical parameters of fatigue
during weaning from mechanical ventilation
Secondary outcome
* Weaning failure parameters
* Patient experience of respiratory fatigue and nurses* estimate of respiratory
fatigue of the patient
Background summary
Patients on the intensive care unit often need mechanical ventilation. In the
last few years it has become clear that mechanical ventilation is harmful for
the diaphragm. This leads to diaphragmatic dysfunction and weakness. The
electrical activity of the diaphragm (EAdi) can be detected by three
electromyography (EMG) methods: transcutaneous EMG, intramuscular EMG and trans
esophageal EMG. Transcutaneous electromyography, also called surface
electromyography (sEMG), is the least invasive method. Optimized monitoring to
specifically monitor fatigue of the respiratory muscles, might accelerate the
weaning process and diminish the length of mechanical ventilation and ICU stay.
Study objective
In this pilot study we aim to investigate the additional value of sEMG signals
of respiratory muscles during ICU admission in adults.
Study design
This is a single center prospective observational cohort pilot study.
Study burden and risks
sEMg is a non-invasive, painless, harmless investigation, which can be
performed at the bedside at the ICU, thus having a negligible risk and burden
for the patient. Patients will not directly benefit from participation in this
study. However, sEMG monitoring of the diaphragm and external intercostal
muscles may benefit patients in the future. Collection of general data from
(electronic) medical records does not affect the patient. Prolonged mechanical
ventilation and weaning is intimately related to the ICU environment.
Therefore, substitution of this patient group is not possible
Meibergdreef 9
Amsterdam 1105AZ
NL
Meibergdreef 9
Amsterdam 1105AZ
NL
Listed location countries
Age
Inclusion criteria
Informed consent
Age 18 years
Expected duration of mechanical ventilation for * 48 hours
Exclusion criteria
(Suspected) neuromuscular disease (other than ICU-AW) or cervical spinal cord injury
Known phrenic nerve injury
Contraindication for electrode placement (e.g. severe skin infection at electrode site)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL50006.018.14 |
| OMON | NL-OMON20779 |