the main objective of this study is to evaluate the ability and reproducibility of high-resolution 3 Tesla MR imaging to visualise intracranial arteries and intracranial atherosclerotic disease in patients with previous TIA or ischemic stroke.
ID
Source
Brief title
Condition
- Central nervous system vascular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The intracranial part of the internal carotid artery, the M1 segment of the
middle cerebral artery and the basilar artery will be imaged. The visibility of
both vessel lumen and vessel wall will be assessed based on the following
parameters:
- Image quality, resolution, signal to noise ratio
- Vascular lumen area on MRI (compared with CTA where available)
- Vessel wall visibility
- Vessel wall thickness
- Contrast enhancement in vessel wall
Secondary outcome
n.a.
Background summary
Atherosclerosis is an important cause of ischemic stroke. Besides the more
widely studied extracranial carotid atherosclerosis, also intracranial
atherosclerotic disease (IAD) is an independent risk factor for ischemic
stroke.1-3 IAD has recently been found to be much more common in the Caucasian
population than previously presumed, highlighting the relevance of adequate
diagnostic methods for the condition.4-6
Assessment of intracranial arteries with CTA, MRA or transcranial Doppler (TCD)
provides information on the degree of luminal stenosis, but not on the vessel
wall. Intracranial vessel wall imaging may enable to determine the underlying
pathology of the intracranial stenosis and thereby make targeted treatment
possible. Also, in the case of atherosclerosis, it may enable to visualise
plaque burden and composition. That might help to identify a subgroup of IAD
patients at the highest risk of stroke and eventually to select patients for
specific therapy. High-resolution MRI has already shown capable of accurately
visualising the vessel wall in extracranial atherosclerosis. Further, promising
results on intracranial vessel wall imaging with 3 Tesla MRI were recently
published.7-10 Our aim is to gain experience with intracranial vessel wall MR
imaging.
Study objective
the main objective of this study is to evaluate the ability and reproducibility
of high-resolution 3 Tesla MR imaging to visualise intracranial arteries and
intracranial atherosclerotic disease in patients with previous TIA or ischemic
stroke.
Study design
single centre, observational feasibility study
Study burden and risks
The risk of participation to this study is low. MRI is a safe imaging technique
without radiation exposure. During the MRI examination patients will have an
intravenous line for gadolinium contrast administration. Side effects of the
MRI contrast agent are rare and usually harmless.
Individual patients will not benefit from participation in this study. The
study will be done in this specific patient group, since patients with previous
TIA or ischemic stroke and vascular risk factors are more likely to have IAD
than patients without.
Meibergdreef 9
Amsterdam 1105AZ
NL
Meibergdreef 9
Amsterdam 1105AZ
NL
Listed location countries
Age
Inclusion criteria
previous TIA or ischemic stroke
>18 yr
two or more vascular risk factors
Exclusion criteria
standard contra-indications to MRI
modified Rankin score >3
renal clearance <30 ml/min
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL48064.018.14 |