To determine the effect of a single red blood cell transfusion on the microcirculation.
ID
Source
Brief title
Condition
- Red blood cell disorders
- Vascular disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Vessel density and microvascular flow index derived from CytoCam imaging.
Secondary outcome
Flow, venous saturation and hemoglobin concentration measured by O2C.
Background summary
The microcirculation is an underexposed new field in neonatal intensive care
medicine. Visualizing the microcirculation can help us understand tissue
perfusion at cellular level. Red blood cell (RBC) transfusion are commonly
administered to premature infants, especially during the first postnatal month.
However in neonates there is a poor relationship between the hemoglobin (Hb) or
hematocrit (Ht) level and clinical symptoms. It would be of great interest to
visualize if there is a beneficial effect of a RBC transfusion at a cellular
level.
Study objective
To determine the effect of a single red blood cell transfusion on the
microcirculation.
Study design
Prospective, observational pilot study.
Study burden and risks
There will be no interference with standard care. The only burdening is four
times skin contact of the CytoCam. The CytoCam is provided with a sterile cap
and uses normal green light. The O2C sensor is an pulse oximetry like sensor
which is placed on the upper arm during the erythrocyte transfusion. The
temperature of the tip of the camera does not increase.
Wytemaweg 80
Rotterdam 3015 CN
NL
Wytemaweg 80
Rotterdam 3015 CN
NL
Listed location countries
Age
Inclusion criteria
- Gestational age below 32 weeks
- Chronic anemia determined by protocol *anemia in preterm infants* of the NICU department
Erasmus MC - Sophia
- Written informed consent
Exclusion criteria
- Any known congenital or chromosomal defects will be excluded from this study.
- Acute bleeding (i.e. pulmonary bleeding, gastrointestinal bleeding)
- Any known hematological disorder (i.e. pathological hemolysis)
- Absence of written informed consent
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL48445.078.14 |