The aim of the project is to test BS6.890C in the prophylactic transplant model of psoriasis.
ID
Source
Brief title
Condition
- Other condition
- Autoimmune disorders
- Epidermal and dermal conditions
Synonym
Health condition
testing drugs using a humanized mouse model of psoriasis
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Not applicable.
Secondary outcome
Not applicable.
Background summary
5mm diameter full thickness skin biopsies from non-lesional skin from a
volunteer with psoriasis, are transplanted onto immune-deficient mice. A
psoriatic lesion is induced in the transplant by injecting autologous white
blood cells into the transplant. Potential drugs can be tested to see if they
prevent development of the psoriasis lesion.
Study objective
The aim of the project is to test BS6.890C in the prophylactic transplant
model of psoriasis.
Study design
Volunteers skin is disinfected and anaesthetised. 3 x 5mm full thickness skin
biopsies are taken from each donor and the biopsy sites closed with a stitch.
The wounds are then covered with a bandage. Wounds are kept dry for 24 hr and
after 7 days the stiches are removed.
Blood (3 x 9ml tubes) is taken in heparinized tubes.
Study burden and risks
The health risks associated with donating the skin biopsies and blood are
small, possibly a small scar and/or discoloration of skin at the biopsy site.
4 rue du Chesnay-Beauregard BP 96205
Saint Grégoire Cedex 35762
FR
4 rue du Chesnay-Beauregard BP 96205
Saint Grégoire Cedex 35762
FR
Listed location countries
Age
Inclusion criteria
Patients with psoriasis vulgaris (light to mild)
Exclusion criteria
Volunteers can not use systemic drugs (for their psoriasis).
Volunteers cannot have UV-light therapy.
Volunteers cannot use immune-modulating drugs for other diseases.
Volunteers should not have problems with the Köbner phenomenon.
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL49848.098.14 |