To evaluate anatomical changes of tumor and organs at risk with MRI before and during radiation treatment.
ID
Source
Brief title
Condition
- Gastrointestinal neoplasms malignant and unspecified
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Analyses:
Rigid match of MRI and CT/CBCT:
- Drawing of GTV volume on MRI and CT
- Mapping of marker position on CT and daily CBCTs
- Evaluation of volume changes preRT MRI compared to MRI in week 3
- Evaluation of marker position compared to MRI volume
- Evaluation of daily marker position on CBCT
- Comparing of organs at risk on CT, CBCT and MRI
- Evaluation of interobserver variation of three delineators
- Analysis of dosimetric consequences of volume changes during radiotherapy
- Analysis of Ktrans en Vp of the 3 MRI scans performed before the start of
treatment
Secondary outcome
Niet van toepassing
Background summary
The tumor and organs at risk change in shape and volume during a 7 week
radiation treatment (1). Our current protocol doesn`t account for these
anatomical changes (2,3). Repeated imaging during treatment is possible with
cone beam CT (CBCT). Soft tissue contrast of tumor and organs at risk however
is insufficient to analyse the anatomical changes. This study is developed to
evaluate the possibilities with MRI to evaluatie shape and volume changes
during radiotherapy. Additionally, the reproducibility of the baseline MRI is
evaluated To this end MRI scans will be performed just before and after
investigation under anesthesia, before start of treatment and in week 3 of the
radiation treatment.
References:
1.Barker JL, Garden AS, Ang KK, et al: Quantification of volumetric and
geometric changes occurring during fractionated radiotherapy for head-and-neck
cancer using an integrated CT/linear accelerator system. Int J Radiat Oncol
Biol Phys 2004, 59:960-970
2.Vasquez Osorio EM, Hoogeman MS, Al-Mamgani A, et al: Local anatomic changes
in parotid and submandibular glands during radiotherapy for oropharynx cancer
and correlation with dose, studied in detail with nonrigid registration. Int J
Radiat Oncol Biol Phys 2008, 70:875-882
3.Hansen EK, Bucci MK, Quivey JM, et al: Repeat CT imaging and replanning
during the course of IMRT for head-and-neck cancer. Int J Radiat Oncol Biol
Phys 2006, 64:355-362
Study objective
To evaluate anatomical changes of tumor and organs at risk with MRI before and
during radiation treatment.
Study design
Single centre, non-randomised, MRI repeat study during radiotherapy
Study burden and risks
Patients with large inoperable oropharyngeal and oral cavity tumors suitable
for chemoradiation usually are planned for PET scan and investigation under
anesthesia with marker insertion for accurate tumor delineation. Before
treatment, two additional MRI scans will be performed just before investigation
under anesthesia and start of treatment. Additionally, during treatment an
additional MRI scan will be performed in week 3. These investigations do not
have major side effects, administration of contrast through an infusion has a
very small risk of contrast reaction, bleeding or infection. The additional
radiation burden for the patient is negliglible compared to the intensive
radiotherapy treatment.
plesmanlaan 121
Amsterdam 1066 cx
NL
plesmanlaan 121
Amsterdam 1066 cx
NL
Listed location countries
Age
Inclusion criteria
- Histology proven squameus carcinoma of oropharynx or oral cavity
- Bulky T2-4, Nx, M0
- Planned for curative radio-chemotherapy
Exclusion criteria
Contra indication for MRI
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL32808.031.10 |