To evaluate the applicability and (cost-) effectiveness of a shortened, partly group based, Cognitive Behavioural Therapy (CBTsa) focussing on social activation in patients with recent onset schizophrenia.
ID
Source
Brief title
Condition
- Schizophrenia and other psychotic disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Negative symptoms, social withdrawal behavior / inactivity
Secondary outcome
Social functioning, Quality of life, cost, Positive and General symptoms, Need
for Care
Background summary
Cognitive Behavioural Therapy (CBT) is one of the most commonly provided forms
of therapy in the Netherlands. It is a short-term, structured therapy that is
sometimes offered groupwise and sometimes individually. In CBT it is assumed
that not the events themselves, but rather thoughts, interpretations and
expectations about these events evoke negative feelings. CBT focuses on
changing both thinking patterns (cognitions) and behaviors. The effectiveness
of cognitive behavioral therapy has often been studied in people with a
psychotic disorder, but research to date has focused mainly on reducing
symptoms such as hallucinations or delusions.
Aaron T. Beck, founder of Cognitive Behavioural Therapy (CBT), and colleagues
have developed and investigated a new CBT approach, in which they target
inactivity in a chronic schizophrenia population with severe negative symptoms
The therapy is based on accumulating evidence that dysfunctional beliefs in
conjunction with neurocognitive impairments can impede functioning. These
results suggest that CBT can be highly successful in establishing clinically
meaningful improvements. However, the therapy has not yet been investigated in
a recent-onset population.
In this study, we particularly focus on maintaining social activities and
reducing symptoms such as a lack of initiative or diminished interest. We
expect that CBT focused on social withdrawal behavior will be effective in
reducing negative symptoms, improving the performance, cost and quality of life
of patients with recent-onset schizophrenia.
Study objective
To evaluate the applicability and (cost-) effectiveness of a shortened, partly
group based, Cognitive Behavioural Therapy (CBTsa) focussing on social
activation in patients with recent onset schizophrenia.
Study design
Single blind randomized controlled trial with 6 month-follow up.
Intervention
Individual and group-based CBT intervention targeting social withdrawal.
Study burden and risks
Patients will undergo a 2-hour during testbattery and will carry along a mobile
device with which participants are prompted by a beep at random intervals
throughout the day (for a 6-day period) to report about their current
experiences and withdrawal behaviour. These assessments will be repeated
post-treatment and at 6-month follow-up. No risks are attached to this study.
Meibergdreef 5
Amsterdam 1105AZ
NL
Meibergdreef 5
Amsterdam 1105AZ
NL
Listed location countries
Age
Inclusion criteria
(1) recent onset schizophrenia (start antipsychotic medication <2 yr);
(2) Social withdrawal (> 3 moderate severity on the PANSS N4; Passive/apathic social withdrawal);
(3) Aged 18-35 years;
(4) Fluent in Dutch
(5) IQ>70;
(6) Able and willing to give informed consent
Exclusion criteria
- Neurological disease or damage that would compromise cognitive functioning
- Negative symptoms as a consequence of positive symptoms, or as a consequence of a physical handicap
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL46776.018.13 |