To assess the differences in the brain responses to food presentation and food choice and how these responses are modulated by hunger and gut signals in normal weight and overweight subjects across the lifespan.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
overgewicht en obesitas
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Neural activation (percentage BOLD signal change) induced by the presentation
of pictures of food and food choice.
Secondary outcome
1. Scores on the liking task & perceived caloric content
2. Gut hormone levels during hungry and satiated condition on several
timepoints.
3. Neural activation (percentage BOLD signal change) in response the execution
of a reward task.
Background summary
Research of food motivation is becoming of increased interest as the prevalence
of overweight and obesity continues to rise in both adults and children. In our
daily lives we are continuously exposed to food. During the day we make many
choices regarding food consumption. Food evaluation and choice both play an
important role in the regulation of food intake and therefore in weight
management. For this reason it is important to obtain more insight into the
mechanisms that underlie these processes.
Study objective
To assess the differences in the brain responses to food presentation and food
choice and how these responses are modulated by hunger and gut signals in
normal weight and overweight subjects across the lifespan.
Study design
Observational study
Study burden and risks
The experiment is non-therapeutic to the subjects and will consist of two study
sessions. On each study day subjects are required to fast overnight. Before a
40-min MRI session on day 1 or 50-min MRI session on day 2, subjects will
execute a computerized liking task in which the food pictures used in the fMRI
tasks are rated on their pleasantness. The MRI paradigm one 15-min, one 5-min
and two (or three on day 2) 10 min MRI scans are made while subjects make food
choices, view pictures of foods and non-food objects, or execute a reward task.
This type of paradigm poses no risk. Functional MRI is a commonly used
technique which is considered to be safe. Additionally, subjects will be asked
to answer several questionnaires on relevant personality traits and eating
behaviour. Furthermore blood will be drawn from the adults and a saliva sample
will be collected from alkl subjects for future DNA analyses. The original LFPQ
(Finlayson, King et al. 2007) will be administered at the end of the last
visit. The children willhave an extra preparatory visit before being scanned.
During this first visit they will engage in a practice session in a MR scanner
simulator. In summary, the risk associated with participation is assessed as
low and the burden as minimal.
Heidelberglaan 100
Utrecht 3584 CX
NL
Heidelberglaan 100
Utrecht 3584 CX
NL
Listed location countries
Age
Inclusion criteria
1.Healthy (self-reported)
2. Age group 1: 8-10, group 2: 13-17, group 3: 25-45 and group 4:65-75 at day 01 of the study
3. Body Mass Index (BMI): between 20 and 25 kg/m2 (normal weight adults) or 25.1 and 35 kg/m2 (overweight adults). For children and adolescents we calculated BMI ranges based on age and gender by using the growth reference data for 5-19 year olds of the World Health Organization (Butte, Garza et al. 2007). A BMI range of -1SD to +1SD in children equals approximately a BMI of 20-25 in adults; A BMI range of +1SD to +3SD in children equals approximately a BMI of 25-35.0 in adults.
4. Right-handed
5. Having given their written informed consent and in children, written informed consent from children and both parents.
6. Willing to comply with the study procedures
7. Willing to accept use of all anonymized data, including publication, and the confidential use and storage of all data
8. Willing to be informed about chance findings of pathology and approving of the disclosure of this information to the general physician (see Informed Consent)
Exclusion criteria
1.Smoking
2.Having a special diet (e.g. to lose weight, medically prescribed diet in the past 6 months, no meat etc)
3.Highly restraint eating (Van Strien et al., 1986).
4.Having a food allergy
5.Having gained or lost >5 kg of body weight in the past 6 months.
6.Having a history of or current alcohol consumption > 28 units per week
7.Having a history of medical or surgical events that may significantly affect the study outcome, such as metabolic or endocrine disease, or any gastro-intestinal disorder
8.Mental or physical status that is incompatible with the proper conduct of the study
9.Not having a general practitioner
10.Participation in any other clinical trial during this study.
11.Working at the Image Sciences Institute or the Radiology Department of the UMC Utrecht as employee or student.
12.MRI exclusion criteria
a)Claustrophobia
b)Having metal implants (i.e. pacemaker, metal joints, prostheses, etc.) or metal objects on the body which cannot be removed (i.e. piercing, hearing aid, brace, etc.
c)Being pregnant.
13. Task related exclusion criteria
a)Unsuccessful satiation of the participant (i.e. hungry after protein shake consumption)
b) Nausea
14. Menopause (applies only to women of age group 1 (25-45 years old))
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL39563.041.12 |
| OMON | NL-OMON26000 |