To evaluate the occurrence of thyroid dysfunction children and young adults with NB and other childhood malignancies , who received diagnostics with 123I-MIBG
ID
Source
Brief title
Condition
- Thyroid gland disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The end-points are TSH, FT4.
Secondary outcome
-
Background summary
The specific uptake and accumulation of 123I-MIBG and 131I-MIBG by
neuro-ectodermal tissues makes the compound suitable for diagnostics and
treatment of neuroblastoma (NB). A drawback of this treatment is that I¯ is
cleaved off from the administered radioMIBG and will be taken up by the
thyroid; reason to protect the thyroid. It was found that, despite protection,
thyroid dysfunction and thyroid nodules may occur. During diagnostics with
123I-MIBG the thyroid gland is also protected. We do not know, however, whether
123I-MIBG is also harmful for the thyroid gland.
Study objective
To evaluate the occurrence of thyroid dysfunction children and young adults
with NB and other childhood malignancies , who received diagnostics with
123I-MIBG
Study design
In the outpatient clinic of the pediatric oncology and the PLEK-poli (Late
Effects Study group), all patients who have received diagnostic radio-MIBG will
be asked to participate. During a routine vena puncture for other reasons, also
blood with be withdrawn for measuring thyrotropin, free thyroxine and
anti-thyroperoxidase antibodies.
Study burden and risks
There is no risk for the patients. During a routine vena puncture for other
reasons, also blood with be withdrawn for measuring of thyroid function.
Meibergdreef 9
Amsterdam 1105 AZ
NL
Meibergdreef 9
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
Children and young adults who received diagnostic 123I-MIBG for suspected neuroblastoma
Exclusion criteria
Children and young adults who received therapeutic 131I-MIBG
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL38114.018.12 |