To study the macro- and microcirculatory effects of VV-ECMO treatment.
ID
Source
Brief title
Condition
- Respiratory tract therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary
1) TTE: Right ventricular function
Secondary outcome
Secondary
1) TTE: Left ventricular function
2) SDF: Proportion of perfused vessels (%)
3) Shunt fraction
Background summary
Veno-venous extra corporeal membrane oxygenation (VV-ECMO) is increasingly
used to treat respiratory failure such as in patients with acute respiratory
distress syndrome (ARDS). However the hemodynamic effects of VV-ECMO have only
been described in neonatal patients and remain to be determined in adults.
Study objective
To study the macro- and microcirculatory effects of VV-ECMO treatment.
Study design
A pilot prospective observational cohort study. We will include patients who
receive VV-ECMO during the period April 1st 2015 - April 1st 2018. Patients
will be subjected to transthoracic echocardiogram (TTE) measurements before and
directly after VV-ECMO initiation as well as 24 hours after ECMO initiation.
Sidestream darkfield imaging (SDF) will be performed at the same time points as
well as a venous blood gas.
Study burden and risks
Patients do not benefit from this study. The additional burden and risks for
patients participating is minimal. Venous blood gas measurements will be taken
from an existing venous line. The hemodynamic measurements we will perform are
non-invasive, not painful and are done while the patient is sedated, minimizing
patient burden.
Meibergdreef 9
Amsterdam 1015AZ
NL
Meibergdreef 9
Amsterdam 1015AZ
NL
Listed location countries
Age
Inclusion criteria
Patients admitted to the intensive care receiving veno-venous ECMO treatement
Exclusion criteria
No exclusion criteria
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL51833.018.15 |