The primary objective is to assess changes in endocannabinoid plasma levels prior, during and after eating of hedonically liked versus non-pleasurable foods.
ID
Source
Brief title
Condition
- Other condition
- Appetite and general nutritional disorders
Synonym
Health condition
Obesitas
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The endocannabinoid plasma profile prior, during and after eating of a
hedonically liked food product compared to a non-pleasurable food product.
Secondary outcome
- plasma levels of ghrelin, GLP1, PP, FFA, glucose and insulin prior, during
and after eating of a hedonically liked food product compared to a
non-pleasurable food product.
- the correlation between eCB profile and FFA profile.
- hunger ratings prior and after eating of a hedonically liked food product
compared to a non-pleasurable food product.
Background summary
The endocannabinoid system has been found to be involved in hedonic eating, but
as of yet it is unknown during what phase(s) of eating, i.e., if the
endocannabinoid system is involved during anticipation and consumption of food
and satiety.
Study objective
The primary objective is to assess changes in endocannabinoid plasma levels
prior, during and after eating of hedonically liked versus non-pleasurable
foods.
Study design
The study has a randomized, cross-over design. In two different sessions
subjects will receive either hedonically pleasant brownie or non-pleasurable
brownie. The two test sessions are at least two weeks apart.
Intervention
NA
Study burden and risks
The study will consist of an intake session that takes 45 minutes, and two test
sessions of approximately 4.5 hours per session on separate days, giving a
total of approximately 10 hours. The study is non-therapeutic for participants.
During each session an intravenous cannula will be inserted and used for blood
drawing, this may cause some discomfort for the participants. The Hb value of
each participants will be determined before participation, blood collection
will therefore not lead to anaemia. Participants will receive their evening
meal and breakfast prior to each test session.
Bomenweg 2
Wageningen 6703 HD
NL
Bomenweg 2
Wageningen 6703 HD
NL
Listed location countries
Age
Inclusion criteria
Male
Healthy
Age: 18-35 years
BMI: 18.5-25 kg/m2
Exclusion criteria
Being allergic for products under study
Not consuming products under study for lifestyle reasons
Endocrine disorder
Use of medication that may influence study outcomes
Smoking >1 cigarette per day
Consuming more than 21 units of alcohol per week
Using cannabis more than 12 times per year
Recent blood donation( <1 month prior to the first test session)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL51830.081.14 |