Goal is to analyse if the extent of Coronary arterial calcification in RA versus type 2 DM patients is equal.
ID
Source
Brief title
Condition
- Coronary artery disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Coronaire Calcium score using the Agatston et. al 1990.
Secondary outcome
Explorative study on Aortic valve calcification using Calcium score discribed
by Agatston et. al 1990.
Background summary
Studies show that RA patients have a higher risk to develope cardiovascular
diseases hich causes atherosclerosis. This increase cardiovascular risk is also
seen in type 2 DM patients; of which periodic testing of the bloodpressure and
labotory test such cholesterol are beeing implemented. Studies show that strict
prevention and therapy help reduce the risk of cardiovascular diseases. Three
ways to measure the extent of atherosclerosis are ultrasound of the carotid
arteries, a scan of the coronary arteries and the aortic valve to measure
arterial - and valve calcification using calculation described by the Agatston
et al 1990.
Study objective
Goal is to analyse if the extent of Coronary arterial calcification in RA
versus type 2 DM patients is equal.
Study design
Cross sectional study with matched RA and type 2 DM population, comparing their
the Coronary Calcium score.
Study burden and risks
Patients need to visit the hospital to undergo the CT-scan, in which they wil
be exposed to save dosis of radiation (equal to 2x dosis of spinal X-ray).
Kleiweg 500
Rotterdam 3045PM
NL
Kleiweg 500
Rotterdam 3045PM
NL
Listed location countries
Age
Inclusion criteria
Inclusion criteria for RA patients:
1) 40-< 60 years old.
2) Established RA according to the American College of Rheumatology 1987 Criteria [39];
3) Participation in the FRANCIS study which implies the availability of at least one recent cIMT measurement.
4) Written informed consent.;Inclusion criteria for type 2 DM patients
1) 40-< 60 years old;
2) Diagnosis of Type 2 Diabetes Mellitus according to national and international guidelines [40, 41];
3) Availability of at least one recent cIMT measurement;
4) Written informed consent.
Exclusion criteria
Exclusion criteria for RA:
1) RA patients with type 1 DM or Type 2 DM;
2) Severely decreased kidney function (MDRD under 30);
3) Cardiovascular event in history: cerebrovascular attack, acute myocardial infarction, CABG, PTCA and amputation, PTA or intermittent claudication due to peripheral artery disease. ;Exclusion criteria for DM type 2:
1) Presence of RA in Type 2 DM patients.
2) Severely decreased kidney function (MDRD under 30).
3) Cardiovascular event in history: cerebrovascular attack, acute myocardial infarction, CABG, PTCA and amputation, PTA or intermittent claudication due to peripheral artery disease.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL49587.101.14 |