To influence social conformity and its neural correlates by entraining orbitofrontal cortex by using transcranial alternating current stimulation.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Niet van toepassing - onderzoek bij gezonde vrijwilligers
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary research outcome: Conformity to different social cues during a decision
task with fictitious monetary reward and punishment after application of tACS.
Secondary outcome
Secondary research outcome: (1) TACS-induced behavioural changes in the
decision task will be correlated with participants' scores on the BIS/BAS
inventory. (2) Change in the rest electroencephalogram (EEG) after tACS. (3)
the effect of reward and punishment on feedback related negativity (FRN) and
late positive potential (LPP).
Background summary
Orbitofrontal cortex (OFC) has shown to be involved in reinforcement-guided
decision making. However, recently it has been shown that social information
that is relevant for decision making is encoded in OFC as well. Previous
studies have shown the importance of intrinsic delta and theta oscillations
during such tasks. Therefore, the present study will further investigate the
relevance and necessity of these oscillations by applying exogenous oscillating
electrical potentials by applying transcranial alternating current stimulation
(tACS). The effects of tACS on behaviour and electroencephalography (EEG)
activity will be investigated.
Study objective
To influence social conformity and its neural correlates by entraining
orbitofrontal cortex by using transcranial alternating current stimulation.
Study design
Placebo controlled double-blind within subjects design.
Intervention
Transcranial alternating current stimulation (tACS) will be delivered by a
battery-driven electric current stimulator (Eldith DC Stimulator (CE 0118),
Ilmenau) using a pair of electrodes: (1) active electrode over the frontal part
of the head (35 cm^2); (2) reference electrode over the central part of the
head (100 cm^2). Stimulation will be delivered for 12 minutes before a social
conformity task. Stimulation comprises either: (1) active delta tACS (2 Hz; 1
mA); (2) active theta tACS (5 Hz; 1 mA); or (3) placebo (sham) tACS (0 mA).
Study burden and risks
The currently proposed tACS procedure and experiment does not carry any
significant risks. Stimulation will be performed in line with the Standard
Operating Procedure Non-Invasive Brain Stimulation of the Donders Institute for
Brain, Cognition and Behaviour. Potential side-effects of tACS are perception
of phosphenes, light tingling, itching or burning sensations on the under the
electrodes, light headache and/or fatigue. These are mild discomforts that
respond promptly to common analgesics. Volunteers can withdraw from the study
at any given time and there are no direct benefits for the participants. The
novel insights will broaden our fundamental understanding of the brain. tACS
offers the unique ability to determine the causal role of brain oscillation
rhythms.
Montessorilaan 3
Nijmegen 6525HR
NL
Montessorilaan 3
Nijmegen 6525HR
NL
Listed location countries
Age
Inclusion criteria
Between 18-35 years of age years; Right-handed; Non-smoking; Normal or corrected-to-normal vision;
Willingness and ability to give written informed consent and willingness and ability to understand the nature and content, to participate and to comply with the study requirements.
Exclusion criteria
(1) Average use of more than 3 alcoholic beverages daily; (2) Use of psychotropic medication or recreational drugs; (3) Skin disease; (4) Pregnancy; (5) Serious head trauma or brain surgery; (6) Neurological or psychiatric disorders; (7) Large or ferromagnetic metal parts in the head (except for a dental wire); (8) Implanted cardiac pacemaker or neurostimulator; (9) Participation in a NBS study in the past 28 days; (10) Previous participation in 10 or more NBS studies.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL54014.091.15 |