Compare the hemodynamic response to pelvic and conventional LBNP and assess head motion.
ID
Source
Brief title
Condition
- Heart failures
- Vascular hypertensive disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
heart rate
stroke volume
head motion
Secondary outcome
blood volume shift
Background summary
Lower body negative pressure (LBNP) is an othostatic test that can be performed
in supine position in an MRI scanner. Application of negative causes the
subject to shift downward possible affecting the MRI measurements. Preventive
measures, such as a saddle and subject fixation straps, have not been able to
sufficiently reduce the motion while remaining comfortable for the subject. We
propose a new type of LBNP box that balances the forces on the subject thereby
reducing the motion.
Study objective
Compare the hemodynamic response to pelvic and conventional LBNP and assess
head motion.
Study design
Observational. Measurements are performed in the Laboratory for Clinical
Cardiovascular Physiology (AMC) and take approximately two hours.
Hemodynamic parameters (including blood pressure, heart rate and stroke
volume), central blood volume (using thoracic impedance measurements) and leg
blood volume (using near-infrared spectroscopy (NIRS) and strain-gauge
plethymography) will be recorded in rest and during 'lower body negative
pressure'. All measurements will be non-invasive.
Study burden and risks
No benefits and risks are anticipated for the subjects in the study population
Meibergdreef 9
Amsterdam 1105 AZ
NL
Meibergdreef 9
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
Age between 18 and 30 years
Non-smoking
BMI between 18 and 28 kg/m2
Height between 160 and 190 cm
Exclusion criteria
Medical history of CV disease, hypertention, diabetes mellitus, pulmonary disease, neurological disease, malignant disease and/or venous insufficiency (as assessed with a questionnaire)
Smoking, or having smoked less than 10 years ago
Use of systemic medication
Alcohol use of > 3 units per day
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL54138.018.15 |