To find the effects in satiety related brain regions and satiety related scores of additional gastric distention with similar nutrient load and oro-sensory exposure.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
algemene fysiologie
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Increase or decrease of blood perfusion signal of brain regions
Secondary outcome
Satiety related scores based on appetite questionnaires, food image
palatability scores and ad lib intake
Background summary
The time food resides in the stomach is relevant for the feeling of *being
full*. Satiety is related to the amount of food consumed, but it is not
completely understood to what extent the effects on satiety exactly stem from
gastric stretching independent of oro-sensory and nutrient effects. Several
areas in the brain are associated with satiety, but all factors modulating
activation in these areas are not yet known.
Study objective
To find the effects in satiety related brain regions and satiety related scores
of additional gastric distention with similar nutrient load and oro-sensory
exposure.
Study design
Randomized cross-over
Intervention
Meal shake with water
Study burden and risks
Potential participants will be invited for an introductory Q&A session where
they can ask questions they may have and get further information on the study.
If still interested, the participants are invited for a screening (30min). For
the study, participants will visit the MRI facility in Hospital Gelderse Vallei
(Ede) two times ( duration approx. 70 min). The subjects will scanned using MRI
to measure their stomach volume before the treatment, and then be asked to
drink a 100mL shake, followed by either a small or a large volume of water.
Questions will be asked about their hunger state and fullness. The study is
non-therapeutic to the participants. The risk associated with participation is
negligible.
Bomenweg 2
Wageningen 6703 HD
NL
Bomenweg 2
Wageningen 6703 HD
NL
Listed location countries
Age
Inclusion criteria
* Male
* Right handed
* Age 18 * 35yr
* BMI 18.5 - 25 kg/m2
* Being healthy (self-reported)
* Having given written informed consent (see E2)
Exclusion criteria
* Not meeting the inclusion criteria
* Drug use or medical conditions which may interfere with normal functioning of the digestive tract
* Drug use or medical conditions which may interfere with normal functioning of the circulatory system
Drug use or medical conditions which may lead to unreliable fMRI results (including, but not limited to neurological conditions)
* Food allergy to or unwillingness to consume the study products
* Reported unexplained weight loss or weight gain of > 5 kg in the month prior to pre-study screening
* Presence of non-removable metal objects in the mouth
* Personnel of Wageningen University, department of Human Nutrition
* Current participation in other research from the Division of Human Nutrition
* Having a contra-indication to MRI scanning
* Disliking the food items.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL53180.081.15 |