To investigate day-to-day reproducibility and validity of PD for assessment of skeletal muscle blood flow during exercise.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
endotheelfunctie arteriën
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Reproducibility:
Difference and agreement (bias and limits of agreement) of changes in blood
volume assessed by PD in the vastus lateralis muscle during maximal and
submaximal exercise on two separate days.
Secondary outcome
Validity:
- Correlation between changes in PD-signal in the musculus vastus lateralis and
changes in blood flow (BF) in the afferent artery measured with pulsed wave
Doppler (PWD) during exercise.
- Correlation between changes in total hemoglobulin (tHb) measured with near
infrared spectroscopy (NIRS) and changes in PD-signal during exercise.
Background summary
One of the factors that influence exercise performance is the ability to
augment blood flow to skeletal muscles during exercise. Therefore, assessment
of blood flow changes in exercising muscles may provide important information
on physiological limitations of exercise capacity in individual subjects (e.g.
athletes, chronic disease). As such, Power Doppler (PD) is a technique capable
of measuring changes in moving blood volume and may therefore be useful to
assess changes in skeletal muscle perfusion. However, before PD can be used in
every clinical practice, it is important to investigate the day-to-day
reproducibility and to validate the PD signal with proven techniques.
Study objective
To investigate day-to-day reproducibility and validity of PD for assessment of
skeletal muscle blood flow during exercise.
Study design
Prospective observational study without invasive measurements.
Study burden and risks
No adverse effects of submaximal cycling exercise performed by healthy subjects
have been reported in literature, nor in our clinical experience. PD, NIRS and
PWD are non-invasive measurements and therefore place no additional burden on
the subjects. In order to set intensity for the submaximal exercise test, all
subjects perform a maximal cardiopulmonary exercise test at baseline. For
healthy subjects (without a cardiovascular condition) there's a very small risk
on getting a ventricular arrhythmia or myocardial ischaemia during a maximal
exercise test. With the inclusion of electrocardiographic analysis and blood
pressure measurements on day 1 during the maximal exercise test, subjects with
myocardial ischaemia and ventricular arrhythmias can be identified and
excluded.
By performing these measurements, we will be able to evaluate the
reproducibility and validity of PD.
De Run 4600
Veldhoven 5504DB
NL
De Run 4600
Veldhoven 5504DB
NL
Listed location countries
Age
Inclusion criteria
Written informed consent
Age 18-50 years
Able to perform a maximal exercise test.
Exclusion criteria
Subjects with risk of adverse events according to abnormal findings in physical examination or the Lausanne questionnaire.
Orthopaedic,cardio-vascular, pulmonary, neuromuscular and other diseases limiting exercise capacity.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL55046.015.15 |
| OMON | NL-OMON24988 |