Primary objectives1) To clarify which components of spatial remapping are impaired after damage to the posterior parietal cortex.2) To correlate spatial remapping abilities with scanpath quality in visual search.3) To examine whether different…
ID
Source
Brief title
Condition
- Vision disorders
- Central nervous system vascular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Spatial remapping abilities as obtained through eye-movement characteristics
(e.g. endpoint error and onset latency) and behavioural responses of location
discrimination (i.e., the ability to accurately judge whether two stimuli were
presented at identical locations). All parameters will be assessed for
different directions of spatial remapping (see last paragraph of introduction)
enabling within-subject analyses.
Secondary outcome
Problems related to spatial remapping deficits encountered in daily life. These
answers will be measured with a questionnaire on a 5-point Likertscale.
Background summary
Spatial remapping is a function of the visual system that enables us to
maintain a stable view of the world when we make eye-movements. This is
beneficial, for example, when searching for a pen on a cluttered desk. Neurons
in the posterior parietal cortex (PPC) are thought to play a crucial role in
spatial remapping. The effect of damage to the PPC on spatial remapping has
been investigated very little and only in small samples (n < 10). Different
studies using different paradigms have yielded conflicting results. With a
larger sample size and three paradigms to test different components of spatial
remapping we will be able to thoroughly assess the consequence of damage to the
PPC on spatial remapping. Moreover, by including only patients of whom
radiological data is available, we can analyse whether different anatomical
subregions within the PPC are differently contributing to spatial remapping.
Study objective
Primary objectives
1) To clarify which components of spatial remapping are impaired after damage
to the posterior parietal cortex.
2) To correlate spatial remapping abilities with scanpath quality in visual
search.
3) To examine whether different anatomical subregions within the PPC are
related to different components of spatial remapping.
Secondary objective
To screen for problems in daily activities that may be related to spatial
remapping, using a short questionnaire.
Study design
Cross-sectional
Study burden and risks
Risks of this study are negligible. All paradigms are non-invasive. Burden for
the subjects is minimal, and only related to the time investment of two visits
at the Department of Experimental Psychology. This research will provide new
explanations cognitive impairments after damage to the PPC and may pave roads
to new approaches in cognitive rehabilitation. The experiments provide no
direct benefit for the subjects.
Heidelberglaan 1
Utrecht 3584 CS
NL
Heidelberglaan 1
Utrecht 3584 CS
NL
Listed location countries
Age
Inclusion criteria
History of clinically diagnosed ischemic stroke affecting the parietal lobe, as verified by MRI or CT data. Stroke can be either first ever or recurrent.
Lesion should be restricted to the right hemisphere, as assessed by inspection of radiological data.
Age between 18 and 85.
Exclusion criteria
Clinical signs of visual field defects, as verified with a short check in the first visit.
Unable to understand instructions of the behavioural paradigms.
Unable to complete eye-tracking calibration procedure.
History of substance abuse.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL53043.041.15 |