The aim of the project is to study the effect of "CD11781/I, CD10394/101A and CD11406/B" on typical skin features of psoriasis. Thisinformation can establish the most effective compound, right formulation and dose for further clinical…
ID
Source
Brief title
Condition
- Epidermal and dermal conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Effect on typical psoriasis skin features after treatment with "CD11781/I,
CD10394/101A and CD11406/B".
Secondary outcome
-
Background summary
Psoriasis is an autoimmune disease in which proinflammatory protein mediators,
released by skin cells and infiltrating cells, cause an abnormal cell division
and differentiation. It may be possible to treat psoriasis using drugs aimed at
preventing the synthesis of such mediators.
Study objective
The aim of the project is to study the effect of "CD11781/I, CD10394/101A and
CD11406/B" on typical skin features of psoriasis. This
information can establish the most effective compound, right formulation and
dose for further clinical research.
Study design
Lesional skin biopsies of 6 mm in diameter will be treated with "CD11781/I,
CD10394/101A and CD11406/B" using the transplant model of psoriasis. By
measuring the effect on typical psoriasis skin features, it is possible to
establish the most effective compound, the right formulation and dose for
further clinical research.
Study burden and risks
The health risks associated with taking blood & skin biopsies are small. It is
possible to obtain a slight scar formation and/or discolouration at the site of
the biopsy punch.
Wytemaweg 80
Rotterdam 3015 CN
NL
Wytemaweg 80
Rotterdam 3015 CN
NL
Listed location countries
Age
Inclusion criteria
Patients with moderate to severe psoriasis
Exclusion criteria
Volunteers undergoing UV/light therapy or taking systemic drugs such as cyclosporin A or methotrexate
Volunteers using local topical corticosteroids
Volunteers developing psoriasis at wound sites (Köbner phenomenon)
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL58081.098.16 |