a pilot study will be performed to gain understanding in cognitive functioning in patients with chronic Q-fever or QFS compared to matched controls.
ID
Source
Brief title
Condition
- Bacterial infectious disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Main study parameters/endpoints: The main study parameters will be cognitive
performance, measured with several neuropsychological tests
Secondary outcome
-
Background summary
After the largest outbreak of Q-fever to date between 2007 and 2011, many
infected persons in the Netherlands struggle with the effects from chronic
Q-fever and Q-fever fatigue syndrome (QFS). There are indications that
impairments in cognitive functioning may be present in these patients. However,
this has never been studied in scientific research before.
Study objective
a pilot study will be performed to gain understanding in cognitive functioning
in patients with chronic Q-fever or QFS compared to matched controls.
Study design
observational, cross-sectional study with assessment of a neuropsychological
test battery. Descriptive analyses and multivariate models will be used to
determine the relation between chronic Q-fever/QFS and cognitive performance.
Study burden and risks
Participants will complete several neuropsychological tests assessed by trained
neuropsychologists. The assessment will take approximately one hour to perform,
and includes widely used tests that measure information processing speed,
memory, attention and executive functioning.
Geert Grooteplein Noord 21
Nijmegen 6525GA
NL
Geert Grooteplein Noord 21
Nijmegen 6525GA
NL
Listed location countries
Age
Inclusion criteria
Patients with chronic Q-fever or Q-fever Fatigue Syndrome and controls from the general population. The pilot study will be performed in a subgroup of patients and controls who gave consent in a previous study (ImpaQt study, CCMO * Nijmegen number *2015-1919*).
Exclusion criteria
Patients with clinical depression (as measured with the Beck*s Depression Index in the ImpaQt study) will be excluded. Participants with medical conditions that cause cognitive dysfunction, (dementia, CVA or other brain injuries, etc .) as well as a history of major psychiatric disorders, will also be excluded.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL58482.091.16 |