The primary aim is to characterize the cerebrovascular and common carotid artery blood flow response to the cold pressor test (CPT). The secondary objective is to explore to potential differences in these cerebrovascular and carotid artery responses…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
hersenaandoeningen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Cerebrovascular perfusion is examined at the level of the middle cerebral
artery using TransCrandial Doppler (TCD, in cm/s) and cerebral cortex using
near infrared spectroscopy (NIRS; concentration oxy/deoxy Hb in mmol/L).
Furthermore, common carotid artery blood flow is measured with ultrasound
(cm/s). These measurements will be performed before and across a 3-minute
period of the CPT.
Secondary outcome
Secundary parameters are ECG (3 lead), blood pressure (Finapres), and end-tidal
CO2.
Background summary
Atherosclerosis is the pathophysiological process underlying cardiovascular
disease. Early detection of cardiovascular risk is possible by identifying
individuals with endothelial dysfunction. Recent work explored the ability to
examine endothelial function by examining carotid artery responses to
sympathetic stimulation using the cold pressor test. To understand the
mechanisms behind blood flow and diameter responses to sympathetic stimulation,
it is important to examine these blood flow responses across several levels of
the cerebrovascular tree.
Study objective
The primary aim is to characterize the cerebrovascular and common carotid
artery blood flow response to the cold pressor test (CPT). The secondary
objective is to explore to potential differences in these cerebrovascular and
carotid artery responses between young and older humans.
Study design
Observational study
Study burden and risks
Participation will cost only one visit of approximately one hour. The
techniques used (TCD, NIRS, US) have no risk for the participants. The CPT may
cause mild discomfort, which is quickly alleviated after the 3 minute time
frame and does not result in any lasting effects. Healthy elderly participants
are preferred, because age is an important confounder for the outcome of these
imaging techniques, while at the same time, the highest prevalence and
therefore clinical relevance of cardiovascular and cerebrovascular disease is
observed in this age group.
Philips van Leijdenlaan 15
Nijmegen 6525 EX
NL
Philips van Leijdenlaan 15
Nijmegen 6525 EX
NL
Listed location countries
Age
Inclusion criteria
* Young adult group: aged 18-30 years
* Elderly group: aged *65 years
* Normal cognition, determined by MoCA Score * 26
* Able to provide informed consent
Exclusion criteria
* Diagnosis of significant neurological or psychiatric diseases relevant for brain function or (cerebral) blood flow (e.g. stroke, dementias)
* History of brain surgery
* Diabetes mellitus, cardiovascular disease, hypertension, epilepsy
* Carotid artery stent or severe stenosis
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL60319.091.16 |