To investigate the effects of anodal and cathodal tDCS on gambling compared to sham stimulation. Additionally, changes in EEG activity will be explored.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Niet van toepassing - onderzoek bij gezonde vrijwilligers
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
TDCS induced changes in gambling as measured by the *certainty equivalent*.
Secondary outcome
TDCS-induced changes in EEG resting state activity.
Background summary
Imaging, lesion and non-invase brain stimulation studies have shown the
importance of the right inferior frontal gyrus (rIFG) in response inhibition.
Recently, imaging studies have suggested that this *braking* mechanisms might
also be involved in gambling. Here, we further explore this idea. The goal is
to provide direct evidence for the involvement of rIFG in gambling by applying
anodal and cathodal transcranial direct current stimulation (tDCS) during a
gambling task.
Study objective
To investigate the effects of anodal and cathodal tDCS on gambling compared to
sham stimulation. Additionally, changes in EEG activity will be explored.
Study design
Placebo (sham) controlled double-blind within subjects design.
Intervention
Online transcranial direct current stimulation (tDCS) will be delivered by a
battery-driven electric current stimulator (Eldith DC Stimulator (CE 0118),
Ilmenau) using two of electrodes, one over rIFG and the other over the
contralateral supra-orbital region (5x7 cm each). Anodal and cathodal tDCS will
be applied at an intensity of 1.5 mA (current density for each electrode: 0.043
mA/cm²). These conditions will be compared to a placebo condition in which sham
tDCS is applied.
Study burden and risks
The currently proposed tDCS procedure and experiment does not carry any
significant risks. Stimulation will be performed in line with the Standard
Operating Procedure Non-Invasive Brain Stimulation of the Donders Institute for
Brain, Cognition and Behaviour. Potential side-effects of tDCS are perception
of light tingling, itching or burning sensations on the under the electrodes,
light headache and/or fatigue. These are mild discomforts that respond promptly
to common analgesics. Volunteers can withdraw from the study at any given time
and there are no direct benefits for the participants. The novel insights will
broaden our understanding of mechanisms of gambling in the brain.
Montessorilaan 3
Nijmegen 6525HR
NL
Montessorilaan 3
Nijmegen 6525HR
NL
Listed location countries
Age
Inclusion criteria
Between 18-35 years of age years; Right-handed; Non-smoking; Normal or corrected-to-normal vision; Willingness and ability to give written informed consent and willingness and ability to understand the nature and content, to participate and to comply with the study requirements.
Exclusion criteria
(1) Average use of more than 3 alcoholic beverages daily; (2) Use of psychotropic medication or recreational drugs; (3) Skin disease; (4) Pregnancy; (5) Serious head trauma or brain surgery; (6) Neurological or psychiatric disorders; (7) Large or ferromagnetic metal parts in the head (except for a dental wire); (8) Implanted cardiac pacemaker or neurostimulator; (9) Participation in a NBS study in the past 28 days; (10) Previous participation in 10 or more NBS studies.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL59220.091.16 |