To test the hypothesis that the correspondence between orosensation of sweetness and post-oral sensation of calories influences REE, CBF and GE.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
fysiologie
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Change in resting energy expenditure in kcal/day
2. Change in gastric emptying rate in mm3/min
3. Change in cerebral blood flow in mL/100*g·min
Secondary outcome
n/a
Background summary
The aim of this study is to test the hypothesis that orosensation influences
carbohydrate metabolism (as measured by resting energy expenditure (REE)) and
regional cerebral blood flow (CBF) by regulating gastric emptying (GE).
Preliminary data from Dr. Small*s laboratory show that when the sweetness of a
flavored beverage is too strong or too weak for a given carbohydrate load (i.e.
*mismatched*), REE and GE are decreased compared to isocaloric beverages where
sweetness and calories are appropriately *matched*.
Study objective
To test the hypothesis that the correspondence between orosensation of
sweetness and post-oral sensation of calories influences REE, CBF and GE.
Study design
2x2 factorial within-participants double blind design, with the factors
sweetness and calories (sweet and high caloric, low sweet and low caloric,
sweet and low caloric (mismatched), and low sweet and high caloric
(mismatched))
Intervention
Calories are manipulated with non-sweet polymer maltodextrin content at two
levels: 75 and 150 kcal. Sweetness is manipulated with sucralose at 2 levels:
equivalent to sweetness of a 75 kcal or 150 kcal beverage sweetened with
sucrose. This yields four combinations. The drinks also have a commercial
flavoring.
Study burden and risks
Each participant will partake in 9 sessions of approximately 1.5 hours each.
During the 4 resting energy expenditure and 4 MRI sessions the participant is
lying down in a comfortable position, but may experience discomfort due to the
MRI coil, and metablic hood which restricts movement. These measurements are
non-invasive and carry minimal risk. The study is non-therapeutic to the
participants.
Stippeneng 4 2
Wageningen 6708 WE
NL
Stippeneng 4 2
Wageningen 6708 WE
NL
Listed location countries
Age
Inclusion criteria
* Right handed
* Age 18 * 35yr
* BMI 18.5 - 25 kg/m2
* Being healthy (self-reported)
* Having given written informed consent (see E2)
Exclusion criteria
* Not meeting the inclusion criteria
* Drug use or medical conditions which may interfere with normal functioning of the digestive tract
* Drug use or medical conditions which may interfere with normal functioning of the circulatory system
Drug use or medical conditions which may lead to unreliable fMRI results (including, but not limited to neurological conditions)
* Food allergy to or unwillingness to consume the study products
* Reported unexplained weight loss or weight gain of > 5 kg in the month prior to pre-study screening
* Presence of non-removable metal objects in the mouth
* Personnel of Wageningen University, department of Human Nutrition
* Current participation in other research from the Division of Human Nutrition
* Having a contra-indication to MRI scanning
* Disliking the food items.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL59671.081.16 |