Examine the effects of a treatment that consists of different natural ingredients on cognitive performance in young healthy subjects. These effects will be compared with caffeine treatment, a natural ingredient that has been found to improve…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
geen aandoening
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary outcome measure is the number of recalled words in a verbal word
learning task.
Secondary outcome
The following secundary measures will be examined in this study:
* The number of words memorized long-term in a verbal learning task.
* De recognition of words in a verbal learning task.
* The number of correct responses in a working memory task.
* The performance on the Stroop to measure attention and inhibition.
* The performance on the Digit symbol substitution task to assess complex
scanning.
* The speeds of responding in combination with correct responses in a
psychomotor task.
Background summary
There is still a great need to find treatments that can improve cognitive
function in old people that suffer from memory and attention problems. There
are various natural ingredients that have been claimed to improve cognitive
functions in humans (e.g., caffeine, L-theanine, vinpocetine). These
ingredients have a different mechanism of action and are assumed to have a
general effect on brain function. It is hypothesized that a combination of
these natural ingredients may be more effective to improve cognitive
performance. In this study we would like to test the cognition-enhancing
potential of a mixture of different natural ingredients.
Study objective
Examine the effects of a treatment that consists of different natural
ingredients on cognitive performance in young healthy subjects. These effects
will be compared with caffeine treatment, a natural ingredient that has been
found to improve cognition in various studies.
Study design
This study will use a double-blind placebo controlled cross-over design.
Intervention
The subjects will be tested three times. At each test session they will receive
one capsule (Placebo, Caffeine, or Combi).
Study burden and risks
The subjects who will be included in the study will visit the testing site four
times (medical screening + practice session, and three test sessions). Each
testing session will last 2.5 h. In total the subjects will spent about 10 h
when they participate. During the three test sessions the subjects will receive
a capsule that contains a placebo, caffeine or a combination of different
natural ingredients. These treatments are well tolerated. No adverse reactions
of treatment are expected. The subjects have to abstain from drinking coffee
and smoking the evening before the test days.
Universiteitssingel 40
Maastricht 6229ER
NL
Universiteitssingel 40
Maastricht 6229ER
NL
Listed location countries
Age
Inclusion criteria
18-35 years of age
Healthy
normal static binocular acuity (corrected or uncorrected)
willingness to sign informed consent
Exclusion criteria
history of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological or
psychiatric illness, are excessive drinking (>20 glasses of alcohol containing beverages a week),
pregnancy or lactation, use of medication other than oral contraceptives, use of recreational drugs
from 2 weeks before until the end of the experiment, and any sensory or motor deficits which could
reasonably be expected to affect test performance. Those volunteers who have a first-degree
relative with a psychiatric disorder or a history of a psychiatric disorder will also be excluded.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL57694.068.16 |