To evaluate the role of white blood cell (WBC) scintigraphy in monitoring the response of infection treatment of a prosthetic joint infection.
ID
Source
Brief title
Condition
- Ancillary infectious topics
- Joint disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The number of re-infections of a prosthetic joint one year after
reimplantation. In the cases with a relapse of infection (caused by the same
micro-organism(s)), the diagnostic value of the WBC scintigraphy in monitoring
the response of infection treatment will be evaluated to define if WBC
scintigraphy can help in deciding when to perform the reimplantation.
Secondary outcome
Not applicable
Background summary
The incidence of a prosthetic joint infection after revision surgery is
approximately 30%. There is no consensus about the timing of reimplantation of
a new prosthetic joint after removal of an infected prosthesis. To verify the
absence of residual infection before re-implanting a new prosthesis is
important in order to prevent a re-infection of the new prosthesis.
Study objective
To evaluate the role of white blood cell (WBC) scintigraphy in monitoring the
response of infection treatment of a prosthetic joint infection.
Study design
In all patients, a WBC scintigraphy will be performed in the 3rd week after
removal of the prosthesis. Additionally, in patients who follow a long interval
before reimplantation a 2nd WBC scintigraphy is repeated 1 week before the
surgery. At the same day of the scintigraphy, inflammatory parameters
(c-reactive protein (CRP) will be measured and clinical parameters will be
recorded.
Study burden and risks
The extent of burden and risks for patients participating in the study is
considered low. If the WBC scintigraphy turns out to be of value in the
monitoring of treatment response during an infection, the WBC scintigraphy will
be implemented in a flowchart of standard care, in order to safely reimplant a
new prosthesis.
Hanzeplein 1
Groningen 9713 GZ
NL
Hanzeplein 1
Groningen 9713 GZ
NL
Listed location countries
Age
Inclusion criteria
Patients >= 18 years, who undergo a 2-stage revision surgery (with a short or long-interval) because of an infected prosthesis of the knee or hip. The indication for a 2-stage revision surgery, as well as the decision for a short or long interval, depend on several (clinical) parameters and is made by a multidisciplinary expert team.
Exclusion criteria
Patients < 18 years, and pregnant or lactating women will be excluded from this study.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL57331.042.16 |