To investigate the effects of in-phase and anti-phase bilateral frontal theta tACS (5 Hz) on gambling behaviour and endogenous frontal theta activity.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
niet van toepassing - onderzoek bij gezonde vrijwilligers
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
TACS induced effects on gambling behaviour as measured by the *certainty
equivalent*.
Secondary outcome
TACS-induced changes in EEG resting state activity.
Background summary
EEG studies have provided evidence for a relationship between frontal theta
activity and gambling behaviour. However, direct evidence is lacking. Using
transcranial alternating current stimulation (tACS) at 5 hz endogenous theta
oscillatory activity can be modulated. Here, we will used bilateral frontal
theta tACS compared to sham tACS to test its effects on a sequential gambling
task. This study will therefore shed more light on the direct role of theta in
gambling.
Study objective
To investigate the effects of in-phase and anti-phase bilateral frontal theta
tACS (5 Hz) on gambling behaviour and endogenous frontal theta activity.
Study design
Placebo controlled double-blind within subjects design.
Intervention
Online in-phase and anti-phase transcranial alternating current stimulation
(tACS) will be delivered by a battery-driven electric current stimulator
(Eldith DC Stimulator (CE 0118), Ilmenau) using two pair of electrodes over
left and right frontal cortex (5x3 cm each). In-phase and anti-phase
stimulation will be applied at a frequency of 5 Hz and an intensity of 1 mA
peak to peak (current density for each electrode: 0.067 mA/cm²). These
conditions will be compared to a placebo condition in which sham tACS is
applied.
Study burden and risks
The currently proposed tACS procedure and experiment does not carry any
significant risks. Stimulation will be performed in line with the Standard
Operating Procedure Non-Invasive Brain Stimulation of the Donders Institute for
Brain, Cognition and Behaviour. Potential side-effects of tACS are perception
of light tingling, itching or burning sensations on the under the electrodes,
light headache and/or fatigue. These are mild discomforts that respond promptly
to common analgesics. Volunteers can withdraw from the study at any given time
and there are no direct benefits for the participants. The novel insights will
broaden our understanding of the brain and may be a basis for future
fundamental and clinical research.
Montessorilaan 3
Nijmegen 6525HR
NL
Montessorilaan 3
Nijmegen 6525HR
NL
Listed location countries
Age
Inclusion criteria
Between 18-35 years of age years; Right-handed; Non-smoking; Normal or corrected-to-normal vision; Willingness and ability to give written informed consent and willingness and ability to understand the nature and content, to participate and to comply with the study requirements.
Exclusion criteria
(1) Average use of more than 3 alcoholic beverages daily; (2) Use of psychotropic medication or recreational drugs; (3) Skin disease; (4) Pregnancy; (5) Serious head trauma or brain surgery; (6) Neurological or psychiatric disorders; (7) Large or ferromagnetic metal parts in the head (except for a dental wire); (8) Implanted cardiac pacemaker or neurostimulator; (9) Participation in a NBS study in the past 28 days; (10) Previous participation in 10 or more NBS studies.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL59225.091.16 |