The aim of the project is to study the effect of chromene derivatives on gene expression in psoriasis lesions. This information can establish the right dose of chromene derivatives for further research.
ID
Source
Brief title
Condition
- Epidermal and dermal conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Gene expression regulation after treatment with chromene derivatives.
Secondary outcome
Not applicable.
Background summary
Psoriasis is an autoimmune disease in which proinflammatory protein mediators,
released by skin cells and infiltrating cells, cause an abnormal cell division
and differentiation. It may be possible to treat psoriasis using drugs aimed at
preventing the synthesis of such mediators.
Study objective
The aim of the project is to study the effect of chromene derivatives on gene
expression in psoriasis lesions. This information can establish the right dose
of chromene derivatives for further research.
Study design
Lesional skin biopsies of 4 mm in diameter will be treated with chromene
derivatives in vitro. By measuring the effect on gene expression, it is
possible to establish the right dose of chromene derivatives for further
research.
Study burden and risks
The health risks associated with taking skin biopsies are small. It is possible
to obtain a slight scar formation and/or discolouration at the site of the
biopsy punch.
Cambridge Innovation Center 1
Massachusetts MA 02142
US
Cambridge Innovation Center 1
Massachusetts MA 02142
US
Listed location countries
Age
Inclusion criteria
Patients with moderate to severe psoriasis
Exclusion criteria
Volunteers undergoing UV/light therapy or taking systemic drugs such as cyclosporin A or methotrexate
Volunteers using local topical corticosteroids
Volunteers developing psoriasis at wound sites (Köbner phenomenon)
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL56245.098.15 |