Objective: to determine the comparability of the liver quantification using the Dixon MRI technique on the Siemens scanner with the MRS technique on the Phillips scanner.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
geen; het betreft een vergelijking van 2 beeldvomende technieken in gezonde personen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Main study parameters/endpoints: Quantification of the liver fat content using
firstly the Dixon MRI technique on the Siemens scanner and secondly the MRS
technique on the Phillips scanner.
Secondary outcome
not applicable
Background summary
Rationale: Proton magnetic resonance spectrometry (1H-MRS) is considered the
gold standard for quantification of liver fat content. However, MRS is
relatively expensive and time-consuming. Therefore, MRI (specifically: mDixon
MRI) is often used as an alternative method. Within the facilities of the
Maastricht University, there are currently 3 options that are regularly used to
measure liver fat percentage. These are the Philips MRI and MRS and the Siemens
MRI technique. Validation of the Dixon MRI technique with the gold standard
technique (MRS) has already been performed for the Philips scanner. However,
validation data are not yet available for the Siemens MRI scanner that is
present on the UM premises
Study objective
Objective: to determine the comparability of the liver quantification using the
Dixon MRI technique on the Siemens scanner with the MRS technique on the
Phillips scanner.
Study design
Study design: Observational study, validation study
Study burden and risks
Nature and extent of the burden and risks associated with participation,
benefit and group relatedness: MRI &MRS do not have any known side effects. Any
beneficial or adverse effects will be null since the results of the additional
MRS scan will not differ from the scan that is already done within the context
of the Maastricht study. The additional scan will take additional time. The
estimated time for the MRS procedure * including transfer between building is
less than 2 hrs
Universiteitssingel 50
Maastricht 6229 ER
NL
Universiteitssingel 50
Maastricht 6229 ER
NL
Listed location countries
Age
Inclusion criteria
Participants must:
(1) Undergo abdominal MRI within the context of the ongoing Maastricht study
(2) Fall within the waist categories <75 cm / 75-85 cm / 85-95 cm/ 95-105 cm/105-115 cm/>115 cm
Exclusion criteria
age<40 yrs and age>75 yrs
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL53972.068.15 |