To assess the reproducibility of the postprandial bile acid response as an outcome of metabolic testing.
ID
Source
Brief title
Condition
- Glucose metabolism disorders (incl diabetes mellitus)
- Glucose metabolism disorders (incl diabetes mellitus)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
postprandial bile acid concentrations expressed as AUC, max peak, time-to-peak
Secondary outcome
postprandial concentrations of the glucose, lipid and thyroid metabolism
expressed as AUC, max peak, time-to-peak. gastric emptying rate.
Background summary
Type 2 diabetes mellitus is a growing burden on health worldwide. Recently,
bile acid metabolism and signalling have
been shown to have positive effects on glucose metabolism in animal models of
metabolic disease. This makes bile
acid research an interesting new avenue in the search for new therapeutic
strategies in diabetes management. We
have previously used the postprandial bile acid response as an outcome of
metabolic testing, but noticed quite some variability.
Study objective
To assess the reproducibility of the postprandial bile acid response as an
outcome of metabolic testing.
Study design
Observational study
Study burden and risks
Burden: 3x6 hours spent at study site, 3x overnight fast, 3x placement of IV
cannula, 300 ml blood drawn total.
Risks: placement of IV cannula risks flebitis and hematoma
Meibergdreef 9
Amsterdam 1105 AZ
NL
Meibergdreef 9
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
healthy young male
age > 18
BMI < 25
Exclusion criteria
Use of any medication
History of cholecystectomy or other bile duct abnormalities
blood chemistry indicating renal or liver disease
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL54162.018.15 |