The current research is set to provide insight into the phenotypic characteristics of DSPD patients in terms of psychological characteristics, occurrence of co-morbidities, and behavioural characteristics such as bedtime routines and lifestyle, and…
ID
Source
Brief title
Condition
- Sleep disturbances (incl subtypes)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary objective of the study is to investigate whether patients with DSPD
suffer more from bedtime procrastination as compared to age- and sex-matched
controls.
A1) A comparison of DSPD-patients* average score on the Bedtime Procrastination
Scale (BPS) compared to age- and sex-matched healthy controls. A2) To evaluate
the correlation between DLMO (Dim Light Melatonin Onset) and the score on the
BPS in DSPD patients, to explore the relation between having a late circadian
rhythm and the degree of bedtime procrastination.
Secondary outcome
B1) To investigate whether DSPD patients show increased reward dependence as
compared to controls.
B2) To evaluate whether subtypes of DSPD patients can be identified with
respect to reward dependence, lifestyle behaviour and occurrence of
co-morbidities.
B3) To provide insight into needs, wishes and pitfalls of DSPD patients with
respect to chronotherapy.
B4) To validate the phase estimation algorithm developed at Philips Research.
Background summary
Delayed sleep-phase disorder (DSPD) is a circadian rhythm sleep disorder.
People with DSPD typically fall asleep some hours after midnight, may
experience long sleep onset latencies and have difficulty waking up in the
morning. Circadian rhythm disorders are often co-morbid with mental disorders
(e.g. depression, anxiety, ADHD, addiction). DSPD is assigned to biological
factors (i.e. genetics), to behavioural factors (lifestyle), or both.
Chronotherapy treatment strategies should be individually adjusted and may be
dependent on the underlying causes of DSPD in the individual. 'Bedtime
Procrastination' is one of the factors that supports the development of DSPD.
Self-control is a crucial factor in the application of chronotherapy and may be
a pitfall of DSPD patients.
Study objective
The current research is set to provide insight into the phenotypic
characteristics of DSPD patients in terms of psychological characteristics,
occurrence of co-morbidities, and behavioural characteristics such as bedtime
routines and lifestyle, and uses this information to increase the effectivity
of chronotherapy interventions by developing new treatment strategies targeting
the individual*s motivation and self-control systems.
Study design
a cross-sectional case-control study
Study burden and risks
Participating in this study is at low risk since the investigational treatment
does not involve any invasive procedures or medicinal products. Wrist-worn
actigraphy, questionnaires and saliva sampling by spitting in a vial, are
non-invasive manners of data collection. The burden for the patient mainly
involves the time investment (completing a total of 9 questionnaires, wearing
actiwatches during two weeks, and saving one evening to perform salivary DLMO
measurements. The DLMO measurement is arranged in such a way that patients can
do this measurement in their home setting, instead of the hospital, which
reduces the burden. For DSPD patients, the desired treatment outcome is an
earlier sleep episode and/or proper management of regular bedtimes. The
ultimate aim is to develop new treatment strategies that will provide clear
therapeutic benefit for the patient.
High Tech Campus 34
Eindhoven 5656 AE
NL
High Tech Campus 34
Eindhoven 5656 AE
NL
Listed location countries
Age
Inclusion criteria
DSPD patients:
-diagnosed with DSPD accruing to the International Classification of Sleep Disorders, ICSD
-age between 18 and 55 years
-score between 6-15 on the Horne Ostberg Chronotype Questionnaire;healthy controls:
-score between 16-32 on the Horne Ostberg Chronotype Questionnaire
-age between 18 and 55 years
-no self-reported (chronic) sleep complaints
Exclusion criteria
• unable to speak and read Dutch.
• vulnerable groups, such as people with psychotic illness, severe intellectual disability, or cognitive dysfunction.
• Shift work or transmeridian flights within 1 month prior to the study
• Presence of other dominant sleep disturbances as apparent from polysomnography examination
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL53284.048.15 |