to determine if there is an alternative mechanism for urine acidification in men in response to NH4Cl other than that through ENaC
ID
Source
Brief title
Condition
- Renal disorders (excl nephropathies)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
urine pH in response to NH4Cl with and without amiloride
Secondary outcome
n/a
Background summary
Distal renal tubular acidosis (dRTA) can be diagnosed using NH4Cl loading or
the furosemide fludrocortisone test (FF test). Recent reports show discrepant
results between the NH4Cl test and the FF test. About 30% of patients with
suspected dRTA show a normal decrease of urine pH after NH4Cl but a disturbed
FF test.
Study objective
to determine if there is an alternative mechanism for urine acidification in
men in response to NH4Cl other than that through ENaC
Study design
an intervention study in which 10 healthy volunteers will undergo two NH4Cl
tests on separate days: one without and the other under treatment with the ENaC
blocker amiloride which is given at two moments during the test.
Study burden and risks
The total number of blood samples is 2 per test. The total number of urine
samples is 8 per test. The risks of the study are negligible. Oral intake of
NH4Cl can cause bad taste and nausea/vomiting.
Geert Grooteplein Zuid 8
Nijmegen 6500 HB
NL
Geert Grooteplein Zuid 8
Nijmegen 6500 HB
NL
Listed location countries
Age
Inclusion criteria
age > 18 years old
Exclusion criteria
any medical history
inability to give informed consent
pregnancy
medication use (except for oral contraceptives)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL62691.091.17 |