Gaining an objective insight in muscle fatigue during exercise for patients with FSHD by 1. comparing the timing of change in sEMG amplitude and sEMG median frequency, to gas exchange variables, heart rate, work load and blood lactate levels during…
ID
Source
Brief title
Condition
- Musculoskeletal and connective tissue disorders congenital
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
sEMG amplitude
sEMG median frequency
Secondary outcome
gas variables (spirometry)
lactate, workload, heart rate
ECG
blood lactate levels
blood pressure
saturation
Borg scale
Background summary
More than 60% of patients with Facioscapulohumeral muscular dystrophy (FSHD)
experiences severe fatigue. Increasing the level of physical inactivity by
aerobic exercises or cognitive behavioural therapy leads to a lower level of
fatigue and a deceleration of the increase of fatty infiltration of upper leg
muscles in these patients. However, the effect of both therapies on exercise
tolerance is unknown. Current outcome measures for exercise tolerance focus on
the cardiovascular system by the use of ergospirometry. For patients with FSHD,
muscle fatigue generally is the limiting factor during exercise. One possible
non-invasive alternative to objectively measure muscle fatigue on the
(neuro)muscular level could be the use of surface electromyography (sEMG).
Study objective
Gaining an objective insight in muscle fatigue during exercise for patients
with FSHD by
1. comparing the timing of change in sEMG amplitude and sEMG median frequency,
to gas exchange variables, heart rate, work load and blood lactate levels
during an incremental cycle test
2. comparing the relative timing of change in sEMG amplitude and sEMG median
frequency in patients with FSHD with the relative timing of change in sEMG
amplitude and sEMG median frequency in healthy subjects
Study design
Explorative cross-sectional proof of concept pilot study
Study burden and risks
The burden and risks associated with participation are neglectable. The task
that need to be performed is safely performed by healthy subjects and FSHD
patients before. CE marked equipment is used.
Reinier Postlaan 2
Nijmegen 6525 GC
NL
Reinier Postlaan 2
Nijmegen 6525 GC
NL
Listed location countries
Age
Inclusion criteria
- aged 18 years and older
- being able to read and understand the Dutch language
- mentally competent
- being able to cycle at least 8 minutes on a bicycle ergometer
Exclusion criteria
- pregnancy
- cognitive impairment
- disabling co-morbidity interfering with the cycle test
- contraindications to Exercise Stress Testing according to the guidelines of the American Heart Association
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL62686.091.17 |