This project aims to determine the validity of a home-based continuous bradykinesia assessment using free typing behaviour analysis. Secondarily, we aim to capture the presence of sequence effect in Parkinson's Disease patients using a computer…
ID
Source
Brief title
Condition
- Movement disorders (incl parkinsonism)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The analyses of the usual typing behaviour will provide two outcomes: typing
cadence and inconsistence in typing cadence. Discriminative function analysis
will evaluate the predictive power of the free typing behaviour to distinguish
between Parkinson's Disease patients, Ataxic patients and healthy controls.
Correlations between 1 - typing cadence or 2 - inconsistence in typing cadence
with validated assessments will be used to determine the validity of typing
cadence in determining the severity of bradykinesia in akinetic patients.
Secondary outcome
This study has one secondary study parameter: the sequence effect. The sequence
effect will be expressed by the sum of keys pressed by the most affected hand
per each second of the test. Sequence effect in the dominant hand will also be
investigated. Furthermore, sequence effect will also be calculated from the
video recording. The intensity of sound will be used to calculate amplitude and
frequency of movement.
Background summary
Bradykinesia is one of the cardinal symptoms of Parkinson*s disease. Objective
measurements, for instance the finger tapping keyboard test, have been
developed as evaluation instruments for this symptom. However, the standardized
and punctual format of the keyboard test is not suitable for continuous
assessment of bradykinesia in a home environment. In addition, the averaged
final score produced by these tools hampers the assessment of a specific
bradykinesia fingerprint: the sequence effect.
Study objective
This project aims to determine the validity of a home-based continuous
bradykinesia assessment using free typing behaviour analysis. Secondarily, we
aim to capture the presence of sequence effect in Parkinson's Disease patients
using a computer based test and sound analysis.
Study design
Observational descriptive study.
Study burden and risks
For Parkinson's Disease patients, the study visit will begin at an OFF status.
Although this visit is expected to take less than 1:30 hours in total (with 30
minutes at OFF status), there is still a small risk of participants feeling
overwhelmed or, for instance, experience a fall episode during the assessment.
To diminish the risk, we have minimized the number of assessments, specially
for Parkinson's Disease patients at an OFF status. In addition, to ensure
safety and efficiency, the assessments will be performed by a trained and
experienced physiotherapist. In any case, if the participant wishes so, the
assessment can be stopped or cancelled at any time. Finally, participants
anonymity is protected during the video recording by not recording any
recognizable body parts, such as the face. Participants are not expected to
directly benefit from the study. However, under their request, clinical and
technical data collected during the study can be made available to them. Once
in their possession, participants are allowed to share them with any health
professional or family member if they wish so.
Geert Grooteplein 21
Nijmegen 6525 EZ
NL
Geert Grooteplein 21
Nijmegen 6525 EZ
NL
Listed location countries
Age
Inclusion criteria
Inclusion criteria for Parkinson's disease and Cerebellar Ataxia only: (1) confirmed idiopathic Parkinson's Disease or Cerebellar Ataxia and (2) presence of slowness of movement. Inclusion criteria for all participants are: (1) usage of a computer with a QWERTY keyboard; (2) 18 years or older at the time of the recruitment; (3) no signs of depression or cognitive impairment; (4) no untreated hearing, visual or upper limb impairment; and (5) ability to provide written informed consent.
Exclusion criteria
The exclusion criteria for healthy elderly is: self-reported history of neurologic disease. For Parkinson's disease and Cerebellar Ataxic patients exclusion criteria are: self-reported incapacitating tremor, dystonia or dyskinesia, and an irregular medication intake scheme.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL64042.091.17 |