To compare the image quality, visibility of perfusion deficits and myocardial blood flow of a conventional analog PET system with a digital PET system in 30 patient referred for PET myocardial perfusion imaging (MPI).
ID
Source
Brief title
Condition
- Coronary artery disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1) The image quality scored on a four points scale, 2) The visibility of
perfusion deficits (existence, location and size) and 3) myocardial blood flow
(global and three coronary trajectories)
Secondary outcome
not applicable
Background summary
Myocardial perfusion imaging (MPI) is important in the diagnostic and
prognostic evaluation of patients with (suspected) coronary artery disease
(CAD). MPI is traditionally performed on single photon emission computed
tomography (SPECT) but the use of positron emitting tomography (PET) is
increasing due to its increased availability; higher resolution, sensitivity
and specificity and the possibility of quantifying myocardial blood flow.
However, high activities of the short-lived PET tracers problems negatively
influence the accuracy of conventional PET systems [1]. A new PET system with
digital photon counting technology may therefore be more suitable. In addition,
this digital PET system has an increased temporal and spatial resolution but
its effect of the image quality or visibility of perfusion deficits in MPI is
still unknown [2, 3]. Isala is one of the first center globally which will be
able to perform MPI on this new digital PET system and patient studies are
lacking.
Study objective
To compare the image quality, visibility of perfusion deficits and myocardial
blood flow of a conventional analog PET system with a digital PET system in 30
patient referred for PET myocardial perfusion imaging (MPI).
Study design
A prospective single center pilot study using intra-individual comparisons
Study burden and risks
The additional MPI PET comprises one extra visit of one hour to the nuclear
medicine department at the Isala hospital in Zwolle. In this hour, patients
will undergo an additional stress procedure using regadenoson (known for its
limited side-effects and discomfort) and will additional Rb-82 activity
resulting in an additional radiation dose of approximately 1.9 mSv. In
comparison, each Dutch citizen receives around 2.5 mSv annually from the
natural environment.
Dr. Van Heesweg 2
Zwolle 8025AB
NL
Dr. Van Heesweg 2
Zwolle 8025AB
NL
Listed location countries
Age
Inclusion criteria
Patient has been refered for Rb-82 PET imaging on a conventional PET
Has to be able to follow the instructions and preparations as needed for additional PET imaging
Able to lie in supine position for 40 minutes
>= 18 years of age
Has to provide written informed consent
Exclusion criteria
A potential subject in whom informed consent is not obtained or does not meet the other inclusion criteria will be excluded from participation in this study. In addition, patients requiring dobutamine for stress imaging because of intolerance of regadenoson (extremely rare) are also excluded.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL63853.075.17 |