To investigate whether perturbation of the left middle temporal gyrus results in immediate adaptation in the right hemisphere, indexed by a shift of alpha-beta oscillatory effects from the left to the right hemisphere.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
onderzoek bij gezonde vrijwilligers
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Alpha-beta oscillations in the EEG as well as naming latencies and error rates
in the language production task following real or sham cTBS
Secondary outcome
AMTs of the left and right primary motor cortex and resting-state EEG prior to
cTBS
Background summary
Language impairment is common after left-hemisphere stroke. However, it is not
clear whether, and if so, how fast the right hemisphere can accommodate for
left-hemisphere lesions. The aim of this study is to investigate whether a
shift of alpha-beta oscillatory effects elicited in a picture naming task from
the left to the right hemisphere can be observed immediately after healthy
speakers receive continuous theta-burst stimulation (cTBS) to the left middle
temporal gyrus (MTG). By transiently disrupting MTG, it is possible to examine
immediate adaptation effects in the contralateral hemisphere. If this is indeed
the case, we hypothesise that cTBS will cause a shift of alpha-beta oscillatory
effects from the left to the right hemisphere. Additionally, left and right
active motor thresholds (AMTs) as well as resting-state EEG will be measured to
investigate whether basal neural activity is predictive for the effects of
cTBS.
Study objective
To investigate whether perturbation of the left middle temporal gyrus results
in immediate adaptation in the right hemisphere, indexed by a shift of
alpha-beta oscillatory effects from the left to the right hemisphere.
Study design
single-blind, sham-controlled, crossover
Intervention
transcranial magnetic stimulation: continuous theta-burst stimulation (three 50
Hz pulses every 200 ms for 40 seconds, 80% AMT) with a Magpro-X-100 magnetic
stimulator (MagVenture, Farum, Denmark)
Study burden and risks
The currently proposed cTBS paradigm does not carry any significant risks.
Safety guidelines as acknowledged by the International Federation of Clinical
Neurophysiology will be followed strictly. Potential side-effects are muscle
tension and headache. These are generally mild discomforts that respond
promptly to common analgesics. Volunteers can withdraw from the study at any
given time and there are no direct benefits for the participants.
Montessorilaan 3
Nijmegen 6525HR
NL
Montessorilaan 3
Nijmegen 6525HR
NL
Listed location countries
Age
Inclusion criteria
Between 18 and 35 years of age* Righthanded* Nonsmoking* Normal or corrected to normal vision* Willingness and ability to give written informed consent and willingness and ability to understand the nature and content, to participate and to comply with the study requirements.
Exclusion criteria
(1) Average use of more than 3 alcoholic beverages daily* (2) Use of psychotropic medication or recreational drugs* (3) Skin disease* (4) Pregnancy* (5) Serious head trauma or brain surgery* (6) Neurological or psychiatric disorders* (7) Large or ferromagnetic metal parts in the head (except for a dental wire)* (8) Implanted cardiac pacemaker or neurostimulator* (9) Participation in a NBS study in the past 28 days* (10) Previous participation in 10 or more NBS studies; (11) epilepsy or family history of epilepsy
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL64141.091.17 |