To investigate the physical, psychological, biological and social factors that are associated with hospitalization-associated disability from hospital admission to three months post-discharge in acutely hospitalized older adults.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
functionele achteruitgang
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary endpoint will be the disability in activities of daily living
(ADL). We will investigate the underlying mechanism behind
hospitalization-associated disability by testing the physical, psychological,
biological and social factors.
Secondary outcome
Secondary outcomes will be the differences in health care utilization, health
related quality of life, and mortality in older hospitalized patients.
Background summary
Over 30% of older patients (70 years and above) hospitalized with an acute
medical illness show a permanent decline in their ability to maintain basic
self-care (i.e., Activities of Daily Living (ADLs), such as bathing, dressing,
transferring out of bed, eating, or walking through the house). This problem is
denoted as hospitalization-associated disability. Despite the high prevalence
of disability after acute hospitalization in older patients, the exact
underlying mechanism behind hospitalization-associated disability remains
unclear.
Study objective
To investigate the physical, psychological, biological and social factors that
are associated with hospitalization-associated disability from hospital
admission to three months post-discharge in acutely hospitalized older adults.
Study design
Longitudinal, prospective, multi-centre, observational cohort study.
Study burden and risks
The underlying physical, psychological, biological and social factors will be
analysed. We plan to interview patients five times (admission, discharge,
1-2-3-12 months post-discharge), using questionnaires. We will also perform
physical measurements at admission and during hospitalization (walking speed,
hand grip strength, muscle mass using bio impedance meter (BIA) and activities
performed during hospitalization by a PAM). The first two measure moments,
during admission and discharge, will be held in the hospital where the subject
is hospitalized. The following follow-ups, at one and three month post
discharge will be held at subjects* home. The two follow-ups, at two and twelve
months post-discharge, will be held by telephone. The blood samples will be
derived from wate products (plasma or serum) of standard venous blood analyses.
If waste material cannot be used, four millilitres of blood will be obtainend
from the customary laboratory rounds. The risks and burdens in this study are
considered to be low.
Meibergdreef 9
Amsterdam 1105AZ
NL
Meibergdreef 9
Amsterdam 1105AZ
NL
Listed location countries
Age
Inclusion criteria
1) acutely admitted to general internal medicine for 48 hours or more;
2) 70 years and older;
3) have approval from the attending Medical Doctor for inclusion;
4) Mini-mental state examination score of 15 or higher (cognitive functioning);
5) able to speak and understand Dutch to complete questionnaires.
Exclusion criteria
1) A life expectancy of three months or less as assessed by the attending MD;
2) Disabled in all six basic ADLs.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL54012.018.15 |