To conduct a pilot study on the relationship between measured sensitivity to reward and the effectiveness of a routine cognitive-behavioral intervention in ADHD. To pilot relevant measurements and generate hypotheses for a larger study in the future…
ID
Source
Brief title
Condition
- Cognitive and attention disorders and disturbances
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Change in the severity of ADHD symptoms as a result of treatment, measured
with the well-validated Strengths and Weaknesses of ADHD and Normal behavior
(SWAN) questionnaire (Lakes, Swanson, & Riggs, 2012).
2. Physiological response to reward as measured by changes in heart rate
variability or skin conductance change during both reward tasks.
Secondary outcome
1. Reward sensitivity as measured by (a) the total reward sensitivity score on
the SPSRQ-C, the Sensitivity to Punishment and Sensitivity to Reward
Questionnaire for children; (b) Reward sensitivity index (response time
distribution shift under rewarded versus non-rewarded conditions) from the
child-friendly version of the Monetary Incentive Delay task and percentage of
advantageous doors chosen from the Hungry Donkey Task (a child-friendly version
of the Iowa Gambling Task).
2. Parental ratings of current stress related to parenting their child, as
measured by the Nijmeegse Ouder Stress Index (NOSI), which is a translation of
the well-validated Parenting Stress Index.
Background summary
Attention-Deficit/Hyperactivity Disorder (ADHD) has been extensively related to
a reduced sensitivity to reward and reinforcement, which is attributed to
dysfunction of the (ventral frontostriatal) reward circuitry of the brain.
However, many research groups now suggest that neurobiological heterogeneity is
present in ADHD, where some individuals are likely to be more affected by
dysfunction of this reward system than others. Standard group
cognitive-behavioral interventions in ADHD are based on reinforcement schedules
in child-centered sessions and on parent training in reward and reinforcement
schedules. However, research shows that such treatments are only modestly
effective. One factor explaining this situation might be that this type of
intervention will be more efficacious in patients with ADHD where lower
sensitivity to reinforcement is not the pivotal area of dysfunction. As such,
our hypothesis is that measured sensitivity to reward will predict symptom
reduction due to a routine cognitive-behavioral intervention.
Study objective
To conduct a pilot study on the relationship between measured sensitivity to
reward and the effectiveness of a routine cognitive-behavioral intervention in
ADHD. To pilot relevant measurements and generate hypotheses for a larger study
in the future.
Study design
Observational study in the context of a routine cognitive-behavioral
intervention for children who have recently been diagnosed with ADHD, and their
parents.
Study burden and risks
Children will be asked to perform neuropsychological tasks lasting up to 2
hours. During one hour of this testing, skin conductance (using two finger
electrodes), and an electrocardiogram (ECG, using two electrodes placed on the
thorax) will be made. No immediate benefits for subjects are to be expected
from participation in this study per se, however, subjects are expected to
benefit from the routine behavioral treatment this study is an add-on to.
Heidelberglaan 100
Utrecht 3584 CX
NL
Heidelberglaan 100
Utrecht 3584 CX
NL
Listed location countries
Age
Inclusion criteria
Inclusion criteria for patients (children with ADHD):
1. Age between 8;6 (8 years and 6 months) and 12;11 (12 years and 11 months).
2. A clinical diagnosis of ADHD (comorbidities are allowed in order to more closely reflect the typical clinical population), that is confirmed using the Disruptive Behavior Disorders Module (Module E) of the Diagnostic Interview Schedule for Children (DISC) (Schaffer, Fisher, Lucas, Dulcan, & Schwab-Stone, 2000).
Exclusion criteria
1. Estimated IQ < 80, since cognitive behavioral treatments are generally not indicated in this IQ range.
2. A known (congenital) cardiovascular disease, since this may influence the ECG and subsequent analyses.
3. History of or present neurological disorder. A neurological disorder is defined as any disorder that requires care from a neurologist.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL47011.041.13 |