The aim of this study is to analyze the long-term effect of full-mouth tooth extraction and subsequent implant placement on the oral microflora (colonization of implants), using 16S next-generation sequencing technique. A secondary aim is to analyse…
ID
Source
Brief title
Condition
- Bacterial infectious disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Changes in relative abundance of bacterial species over time as analysed by 16S
next generation sequencing technique.
Secondary outcome
Not applicable
Background summary
Full-mouth tooth extraction significantly changes the oral microflora. These
changes include reduction of A. actinomycetemcomitans and P. gingivalis,
frequently to levels below detection threshold. However, in some patients, A.
actinomycetemcomitans and P. gingivalis can persist in the edentulous oral
cavity up to 3 months after full-mouth tooth extraction. Nowadays many fully
edentulous subjects receive dental implants to support their full prosthesis.
It is currently unknown if periodontal pathogens persist in the oral cavity in
the long-term and if persisting periodontal pathogens pose a risk for dental
implants (increase the risk for development of peri-implant infections.)
Study objective
The aim of this study is to analyze the long-term effect of full-mouth tooth
extraction and subsequent implant placement on the oral microflora
(colonization of implants), using 16S next-generation sequencing technique. A
secondary aim is to analyse the effect of remaining periodontal pathogens on
long-term implant success.
Study design
The present study is a prospective cohort study.
Study burden and risks
No risks are involved with participation in this study. Full-mouth tooth
extraction will be performed by the patient*s own dentist (regular dental
care). Microbiological samples will be obtained by the researcher from various
locations in the oral cavity prior to full-mouth tooth extraction and 3 months
and 1 year, 3 years, 5 years, 7 years and 9 years after full mouth tooth
extraction. To minimize the burden, research appointments will be combined with
regular visits to the patient*s own dentist.
Antonius Deusinglaan 1
Groningen 9713 AV
NL
Antonius Deusinglaan 1
Groningen 9713 AV
NL
Listed location countries
Age
Inclusion criteria
1) The patient is >= 18 years of age;
2) The patient has a hopeless residual dentition of at least 4 teeth for which extraction of all teeth is the only remaining treatment modality.
3) The patient is diagnosed with mild or severe periodontitis (2 approximal sites with at least 2 mm of clinical attachment loss or probing pocket depth of at least 5 mm).
4) The patient is capable of understanding and giving informed consent.
Exclusion criteria
1) Medical and general contraindications for the surgical procedures;
2) A history of local radiotherapy to the head and neck region;
3) Chemotherapy in the previous 6 months;
4) Systemic or local use of antibiotics in the oral cavity during the last 3 months;
5) Use of anti-septic / antimicrobial therapies (including mouthrinses) in the oral cavity during the last 4 weeks;
6) Patients with dental implants remaining in the oral cavity after full-mouth tooth extraction.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL60374.042.16 |