To study microcirculatory perfusion in living kidney donors before and after donation.
ID
Source
Brief title
Condition
- Heart failures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main endpoint is to assess if perfused vessel density (PVD) in living
kidney donors will be decreased after donation
Secondary outcome
1) total vessel density (TVD)
2) eGFR
3) serum RAAS markers (aldosterone/renine ratio), FGF-23, insulin resistance
markers (HOMA-IR), inflammation markers (hs-CRP and IL-6) levels
Background summary
Recent studies comparing equally healthy controls with donors suggest that
living kidney donation is associated with increased risk of developing
cardiovascular disease (CVD). However, mechanisms underlying this possible
association remain unknown. In this study, we aim to investigate whether
microcirculatory perfusion becomes compromised after unilateral nephrectomy in
living donors in order to get more insight in the possible mechanism behind the
development of CVD after kidney donation.
Study objective
To study microcirculatory perfusion in living kidney donors before and after
donation.
Study design
Single center, prospective observational study
- Sublingual microcirculation measurements take place one day before surgery
and two weeks after surgery.
- Blood sampling to determine levels of serum RAAS markers (aldosterone/renine
ratio), FGF-23, insulin resistance markers (HOMA-IR) and inflammation markers
(hs-CRP and IL-6)
Study burden and risks
Imaging of the sublingual microcirculation is a non-invasive technique, with
minimal burden for the patient. Therefore, risks associated with participation
are negligible.
De Boelelaan 1117
Amsterdam 1081 HV
NL
De Boelelaan 1117
Amsterdam 1081 HV
NL
Listed location countries
Age
Inclusion criteria
Age > 18
Living kidney donors
Provision of written informed consent
Exclusion criteria
If candidate cannot understand Dutch or English.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL65200.029.18 |
| OMON | NL-OMON20333 |