Relationship between chronic sleep deprivation and AD
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Neurodegeneratieve ziekten
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Amount of SWS during one night of polysomnography, total score on cognitive
testing
Secondary outcome
- Difference in duration of SWS between maritime pilots and controls (PSG);
- Brain amyloid load in maritime pilots (compared to normative population-based
values);
- Cortical and hippocampal atrophy in maritime pilots;
- DMN activity in maritime pilots;
- Cognitive effort trade-off in maritime pilots;
- Functional and structural connectivity in maritime pilots;
- Presence of small vessel disease (SVD) in maritime pilots;
- Cerebral blood flow in maritime pilots.
Background summary
Recent evidence shows a bi-directional relationship between poor sleep and
Alzheimer*s disease (AD). Sleep disorders are more frequent and severe in AD
patients compared to normal aging, and in turn, poor sleep seems to have a
causal role in the pathology of AD by influencing the clearance and production
of the amyloid beta protein. However, the effect of chronic sleep deprivation
on cognitive decline and AD has not been investigated. To demonstrate the
effect of chronic sleep deprivation for over a period of time, we will perform
a controlled trial in a group that has an extrinsic cause of their poor sleep.
Study objective
Relationship between chronic sleep deprivation and AD
Study design
An observational case-control study in male Dutch maritime pilots, aged 55-60
(n=20) and age-matched volunteers (n=20). Both groups will first wear an
actiwatch for 2 weeks. Participants will then have one night of polysomnography
with neuropsychological testing the following morning. In the next phase, the
maritime pilots will undergo PET-CT and MRI scans, on separate measurement
days. In the two weeks preceding these scans, the maritime pilots will use the
wearable SmartSleep device during their sleep to measure the duration and
quality of sleep.
Study burden and risks
De proefpersonen zullen in totaal 4 bezoeken hebben, waarin wordt verwacht dat
zij tijdens het tweede bezoek een nacht polysomnografie hebben op locatie. Wij
verwachten een minimaal risico voor onze proefpersonen, de stralingsbelasting
van de PET-CT is gering. Er kan irritatie zijn door het langdurig dragen van
het actiwatch horloge of het aanbrengen van de electrodes voor polysomnografie
voor mensen met een gevoelige huid.
The study consists of 4 visits, with one night of polysomnography on location
(visit 2). We expect minimal risks for the participants, the radiation exposure
is minimal. As there is risk of accidental findings, all PET-CT and MRI will be
read by a trained physician. The investigator will consult the physician of
this study in case a report is made of an incidental finding, other than
age-appropriate brain damage (mild general atrophy and white matter lesions).
In case a clinically relevant incidental finding is made, the subject will be
contacted by the physician to discuss the finding. If needed, appropriate steps
are taken to handle the incidental finding (additional examinations,
treatment).
Reinier Postlaan 4
Nijmegen 6525 GC
NL
Reinier Postlaan 4
Nijmegen 6525 GC
NL
Listed location countries
Age
Inclusion criteria
Maritime pilots, -Written informed consent
-Age 50-60
-Male
-Subject is in good health as established by medical history
-Medication free, Healthy volunteers
-Written informed consent
-Age 50-60
-Male
-Finished HBO education
-Subject is in good health as established by medical history
-Medication free
-Normal sleep behavior, Pittsburg Sleep Quality Index score of <5
-Sleep schedule within the range of bedtime 8PM-12AM and waketime 4AM-8AM
Exclusion criteria
-Self reported difficulty in sleeping in unfamiliar environment
-Use of sedative-hypnotic medication
-Abnormal movement of the non-dominant arm
-Inability to understand Dutch
- Subjects with contra indications for PET-CT and/or MRl, e.g. due to
claustrophobia, metal in upper body, have an implant or who suffer from
epilepsy.
Subjects who are currently participating in another study or have participated
in a clinical study within 30 days, based on their own report about
participation history
-Subjects with a history of drug or alcohol abuse
-Subjects who are part of the study staff personnel or family members of the
study staff personnel
-Neurological disorder (stroke, dementia, epilepsy, brain trauma)
-Subjects who wish not to be informed of accidental findings in the PET-CT
and/or MRI part of this study.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL55712.091.16 |