Elucidation of the pathogenic role of cornea-infiltrating HSV-specific T-cells in HSK patients.
ID
Source
Brief title
Condition
- Ocular infections, irritations and inflammations
- Viral infectious disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Characteristics of HSV-specific T-cells in diseased cornea tissue specimens of
HSK and non-HSK patients.
Secondary outcome
None
Background summary
Herpes simplex virus type 1 (HSV-1) infection of the cornea may lead to
herpetic stromal keratitis (HSK), a major cause of corneal blindness worldwide.
Cornea-infiltrating HSV-specific T-cells are considered pivotal in the
pathology of HSK, but their phenotype, viral antigen specificity and effector
mechanisms remain largely unknown. Detailed characterization of virus-specific
T-cells in surplus post-transplant corneal specimens from patients with HSK,
and non-infectious cornea disorders (non-HSK) included as disease controls, may
provide clues to develop new intervention strategies aimed to inhibit their
pathogenic effector function.
Study objective
Elucidation of the pathogenic role of cornea-infiltrating HSV-specific T-cells
in HSK patients.
Study design
Prospective, non-randomised and observational
Study burden and risks
Participants do not benefit directly, risks are negligible, and burden is low.
'Gravendijkwal 230 Ee1720a
Roterdam 3015GE
NL
'Gravendijkwal 230 Ee1720a
Roterdam 3015GE
NL
Listed location countries
Age
Inclusion criteria
Age >= 18 years.
Immunecompetent individual.
Positive HSV-1 infected
Documented ocular disease history for at least 1 year.
Indication for therapeutic corneal transplantation*
Exclusion criteria
Individuals with documented HIV, HBV or HCV infection.
Individuals on immune therapy or did so in the past 3 months.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
CCMO | NL71647.078.19 |