(1) Study consequences of prenatal undernutrition for cognitive function and brain parameters in older age; (2) Study consequences of prenatal undernutrition for age-related changes in cognitive function and brain parameters; (3) Study DNA…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
cognitieve en hersenveroudering; neurodegeneratieve aandoeningen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
In a subsample of 200 cohort members, we will measure cognitive function by
applying neuropsychological testing, brain parameters by means of a
neuroimaging protocol.
Secondary outcome
Secondary study parameters are DNA methylation differences .
Background summary
In studying determinants of cognitive aging and neurodegenerative diseases such
as dementia, research focus has mostly been on genetic background and lifestyle
factors in adulthood. During the past two decades though, it has become
increasingly clear that the foundations for brain functioning in later life are
laid down in utero and adverse conditions during the prenatal period may
increase the risk for the development of premature cognitive decline and
neurodegenerative diseases. The Dutch famine birth cohort study provides the
unique opportunity to investigate whether conditions in utero may indeed relate
to accelerated cognitive decline and brain aging.
We hypothesize that exposure to undernutrition during gestation is associated
with increased symptoms of cognitive and brain aging and that differences in
cognitive and brain aging between individuals prenatally exposed and unexposed
to undernutrition are associated with differences in DNA methylation levels.
Study objective
(1) Study consequences of prenatal undernutrition for cognitive function and
brain parameters in older age;
(2) Study consequences of prenatal undernutrition for age-related changes in
cognitive function and brain parameters;
(3) Study DNA methylation in relation to prenatal famine exposure and cognitive
and brain aging.
Study design
Cohort study
Study burden and risks
Participants will be invited for a visit to the clinic for measurements.
Measurements will include: blood withdrawal (20 ml), blood pressure,
anthropometry (height, weight, waist, hip and head circumference), MRI of the
brain, and a cognitive test battery. Furthermore, a standardized interview will
be administered asking about lifestyle, medical history, medication use and
mood symptoms. The estimated total time that measurements will take is about 3
hours. Physical burden will be minimal with blood withdrawal and MRI as the
most discomforting measurements.
Meibergdreef 9
Amsterdam 22660
NL
Meibergdreef 9
Amsterdam 22660
NL
Listed location countries
Age
Inclusion criteria
The Dutch famine birth cohort consists of around 2400 people who were born around the time of the Dutch famine. For the present study we will randomly select a subsample of 40 participants per study group (born before famine, exposed to famine during early, mid or late gestation and conceived after famine), in total 200 participants, starting with those who also particpated in a study we performed in 2012. Those wo are still alive, living in the Netherlands with known contact information are eligible for participation.
Exclusion criteria
Cohort members who are unable to visit the clinica due to mental or physical illness.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL67970.018.19 |