Objective: - describe and monitor the molecular epidemiology of HCV in MSM in Amsterdam- determine HCV transmission networks in MSM- determine the factors associated with HCV transmission networks- determine role of HIV positive MSM who acquire…
ID
Source
Brief title
Condition
- Viral infectious disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- Dynamics of the phylogenetic transmission clusters
- Sexual network related parameters including timing, location, and method of
meeting sexual partners
Secondary outcome
not applicable
Background summary
Despite impressive uptake of direct-acting antivirals for Hepatitis C virus
(HCV) in the Netherlands among HIV/HCV co-infected men who have sex with men
(MSM), HCV transmission continues, especially among patients previously
successfully treated for HCV. The incidence of reinfection occurs at the
extremely high rate of 15 per 100 person-years. Moreover, HCV transmission also
occurs in high risk HIV negative MSM, particularly in PrEP users. Clearly, to
eliminate HCV from the MSM population, more information is needed on
transmission dynamics to identify the sources and timing of new HCV infections.
Real-time information on transmission dynamics could guide public health
services in their preventive efforts.
Study objective
Objective:
- describe and monitor the molecular epidemiology of HCV in MSM in Amsterdam
- determine HCV transmission networks in MSM
- determine the factors associated with HCV transmission networks
- determine role of HIV positive MSM who acquire acute HCV in HCV transmission
to HIV negative MSM (including MSM taking PrEP)
- monitor changes in sexual network characteristics over time
Study design
Open prospective observational cohort. The study is the reduced and revised
version of the MOSAIC-2 cohort study that started in 2009 (NL26485.018.09, AMC
MEC 09/023).
Study burden and risks
Data collection for this study will be performed as much as possible in
accordance with the diagnostic interventions in the regular care of these
patients. For individuals with an acute HCV infection, extra interventions for
data collection will consist of:
- Extra serum collection during regular venapunctions after acute infection
- Filling in a questionnaire on timing, location, and method of meeting sexual
partners in the past 6 months at inclusion and during 2-year follow-up
Meibergdreef 9
Amsterdam 1105AZ
NL
Meibergdreef 9
Amsterdam 1105AZ
NL
Listed location countries
Age
Inclusion criteria
o Male
o Having sex with men
o 16 years or older
o With or without HIV infection
o Acute HCV infection according to our definition
o Presumed acquisition of acute HCV infection via sexual transmission
Exclusion criteria
Inability or unwillingness to provide informed consent or follow the
requirements of the study
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL70267.018.19 |