To investigate lingual articulation and coarticulation as well as variability of speech in children with DMD, as compared to their healthy peers. This information will lead to a better understanding of how speech is impacted by DMD and will…
ID
Source
Brief title
Condition
- Other condition
- Musculoskeletal and connective tissue disorders congenital
- Muscle disorders
Synonym
Health condition
speech deterioration
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are tongue movements during the production of speech.
Anticipatory coarticulation will be analysed.
Secondary outcome
Secondary study parameters include the analysis of syllable duration, syllable
periods, and peak intensity as well as formants.
Background summary
Due to a lack of a protein called dystrophin, DMD patients suffer from
progressive muscle degeneration. As speech requires subtle motor movements and
muscle coordination, it is commonly found to be affected in DMD patients. These
language and speech issues are recognizable from a very early age, and in some
cases, children with DMD were diagnosed due to speech therapy referral. It has
also been shown that older DMD patients suffer from articulation issues and
enlargement of the tongue. Previous studies have pinpointed the breakdown of
oral muscles at the age of 8 but the exact start of articulation difficulties
is yet unknown. This pilot study aims to examine the effect of age on speech
development in DMD children in order to determine how the development differs
from that of healthy children. This could highlight the potential role of
speech in the diagnosis of DMD and, in the long term, help improve speech
therapies.
Study objective
To investigate lingual articulation and coarticulation as well as variability
of speech in children with DMD, as compared to their healthy peers. This
information will lead to a better understanding of how speech is impacted by
DMD and will ultimately aid in improving speech therapy for DMD patients
Study design
The participants will perform several speech tasks. During these tasks, tongues
movements will be recorded using ultrasound tongue imaging (UTI). The data from
the DMD patients will be compared to the data from non-speech disturbed
controls
Study burden and risks
No known risks or benefits are associated with participation in this study.
Participants will be tested during the annual Duchenne Congress in May 2020.
Before the experiment takes place, a full explication and consent form will be
described to the parents and the child participating. Subsequently, the
researcher will place the helmet of the UTI on the participant*s head and
position the UTI probe under the chin. Setting up the equipment will take
approximately 5 minutes. The participants will then be asked to produce words
and non-words during four speech tasks, taking approximately 25 minutes.
Oude Kijk in 't Jatstraat 26
Groningen 9712 EK
NL
Oude Kijk in 't Jatstraat 26
Groningen 9712 EK
NL
Listed location countries
Age
Inclusion criteria
-Mother tongue speaker of Dutch
-Between 4 and 12 years old
Only for the DMD group:
-Duchenne Muscular Dystrophy diagnosis.
Only for the healthy control group:
-No history of speech problems
Exclusion criteria
-Younger than 4 years of age / older than 11 years of age
-Severe swallowing problems
-Participants who are not able to follow directions due to severely compromised
cognitive abilities.
-Participants with severe hearing problems will not do the shadowing task of
words and non-words.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL71147.042.19 |