To study the progression of high and pathologic myopia over time.
ID
Source
Brief title
Condition
- Retina, choroid and vitreous haemorrhages and vascular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Progression of myopia/myopic maculopathy.
Secondary outcome
Visual acuity, axis length, visual field, OCT (retinal anatomy).
Background summary
Pathologic myopia is a type of high myopia that is characterized by the
presence of chorioretinal atrophy, staphylomas and/or choroidal
neovascularization. These abnormalities make pathologic myopia one of the main
contributors to impaired vision and blindness worldwide. Our understanding of
high and pathologic myopia is mainly based on large follow-up studies from
Asian countries. It is unclear whether the knowledge obtained from Asian
studies also applies to Caucasian patients. From clinical experience, it seems
that Caucasian high and pathologic myopia acts differently from the described
Asian studies. For example, in Asia most patients with a myopic choroidal
neovascularization only need one anti-VEGF injection. While in contrast, most
Caucasian patients need more injections and have frequent recurrences.
Study objective
To study the progression of high and pathologic myopia over time.
Study design
Prospective, longitudinal study
Study burden and risks
This is an observational study, risks are negligible, burden is moderate.
Duration of the study is 3 years and involves 6 visits to the REH. Two visits
take about 1 hour each, the other four visits will take 3 hours each.
Schiedamse Vest 180
Rotterdam 3011 BH
NL
Schiedamse Vest 180
Rotterdam 3011 BH
NL
Listed location countries
Age
Inclusion criteria
Age >= 40 years;
Highly myopic refractive error
Caucasian background.
Exclusion criteria
Visual acuity > 0.7 logMar at baseline
Ocular media of inadequate clarity to permit high quality fundus imaging
Previous ocular trauma
Keratoconus
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL71597.078.19 |