Objective: to investigate calcium containing crystal release in synovial fluid after exercise as drivers of synovitis in post-traumatic versus non-post traumatic osteoarthritis.
ID
Source
Brief title
Condition
- Joint disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Baseline concentrations and change in crystal concentration before and after
exercise in post-traumatic arthritis, post-traumatic OA versus non
post-traumatic OA
Secondary outcome
Correlation between crystals in blood and synovial fluid with inflammatory
mediators and leucocyte activation
Background summary
Calcium containing crystal release in synovial fluid after exercise may drive
of synovitis in post-traumatic versus non-post traumatic osteoarthritis. They
may also cause arthritis soon after initial joint trauma.
Study objective
Objective: to investigate calcium containing crystal release in synovial fluid
after exercise as drivers of synovitis in post-traumatic versus non-post
traumatic osteoarthritis.
Study design
Study design: Exploratory biologic analyses in a transversal patient cohort.
Study burden and risks
Intervention: blood sampling, synovial fluid sampling before and after physical
exercise.
Nature and extent of the burden and risks associated with participation,
benefit and group relatedness:
A study visit involving clinical examination, blood and synovial fluid
withdrawal. Risk score classification: low.
Geert Grooteplein-zuid 10
Nijmegen 6525GA
NL
Geert Grooteplein-zuid 10
Nijmegen 6525GA
NL
Listed location countries
Age
Inclusion criteria
1. 20 patients with a recent anterior cruciate ligament injury
2. 20 patients with a recent meniscal injury
3. 20 patients with post-traumatic osteoartrhritis.
Group 1
18 years or older
Recently (<2 months) suffered a cruciate ligament injury of the index knee.
a swollen joint
Group 2
18 years or older
Recently (<2 months) suffered a meniscal injury of the index knee.
a swollen joint
Group 3
18 years or older
Knee OA according to the clinical ACR criteria for knee OA
Suffered a knee injury (e.g. ligament rupture with subsequent reconstruction)
before development of OA in the index knee
a swollen joint
Exclusion criteria
Patients with an active inflammatory or infectious co-morbid disease
Knee prosthesis
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL66356.091.18 |