The objective of this study is to investigate the effects of stimulation of noradrenaline and acetylcholine and the blockade of NMDA-receptors on neural and behavioral measures of perception and consciousness.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Geen aandoening, dit onderzoek richt zich op de werking van het gezonde brein.
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary study parameters include behavioral reaction times and performance
scores and EEG-, MEG- and fMRI-measures.
Secondary outcome
Not applicable
Background summary
Fluctuations in global brain state, modulated by noradrenaline and
acetylcholine, possibly affect conscious perception. In addition, evidence
suggests that recurrent processing, which is thought to be crucial for
conscious perception, is dependent on NMDA-receptor activity. In the proposed
study we aim to provide causal evidence for the roles of these neurobiological
factors in conscious perception.
Study objective
The objective of this study is to investigate the effects of stimulation of
noradrenaline and acetylcholine and the blockade of NMDA-receptors on neural
and behavioral measures of perception and consciousness.
Study design
This study will use a within-subject, double-blind, placebo-controlled
randomized crossover design.
Intervention
Participants will receive 40mg atomoxetine, 5mg donepezil, 20mg memantine or
placebo on four different test sessions, in a randomized order.
Study burden and risks
Participants will have to visit the lab 3 to 5 times, depending on the specific
study part in which they participate. One of these visits is the initial intake
session, the others are testing days. On these testing days, participants will
perform simple computer tasks, while their brain activity is measured with EEG,
MEG or fMRI. In addition, participants will receive 40mg atomoxetine, 5mg
donepezil, 20mg memantine or placebo on each testing day. Before and after
testing days, participants have to adhere to some simple restrictions
concerning the intake of alcohol, drugs and caffeïne and operating motorized
vehicles.
De used products can cause side-effects, including dizziness, nausea and
headaches. Previous studies using single doses of these products show, however,
that they are well-tolerated. Considering the extensive exclusion criteria,
screening procedure, constant monitoring of participants and the fact that they
only receive single, subtherapeutic doses of these products, we do not expect
any serious side-effects.
Nieuwe achtergracht 129
Amsterdam 1018WS
NL
Nieuwe achtergracht 129
Amsterdam 1018WS
NL
Listed location countries
Age
Inclusion criteria
Healthy volunteers between 18 and 30 years old;
Native Dutch speakers;
Predominant right-handedness;
BMI between 18.5 and 30.
Male
Exclusion criteria
Current or history of any medical or psychiatric disorder or disease
Smoking
Allergy for atomoxetine, donepezil, memantine or one of the inactive
ingredients of these products
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL64341.018.18 |