To determine the differences in muscular activity of the diaphragm between children with controlled asthma, uncontrolled asthma, dysfunctional breathing patterns and healthy children.
ID
Source
Brief title
Condition
- Respiratory tract infections
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The changes in muscular activity and spirometry will be compared to their
baseline values to determine the decrease in lung function, as well as the
increase in muscular activity in response to exercise. Muscular activity will
also be compared to spirometry in order to establish the correlation between
muscular activity and lung function changes.
Secondary outcome
Non-applicable
Background summary
Exercise induced bronchoconstriction (EIB) is a highly specific symptom for
childhood asthma. The muscular activity of the diaphragm is known to be closely
related to the pulmonary function measured with spirometry. We aim to
investigate the use of the non-demanding EMG measurements as an alternative
measure in childhood asthma.
Study objective
To determine the differences in muscular activity of the diaphragm between
children with controlled asthma, uncontrolled asthma, dysfunctional breathing
patterns and healthy children.
Study design
The study will have a cross sectional design, in which all children are exposed
to the same exercise protocol. Asthma control will subsequently be determined
by a paediatrician. Children will perform their scheduled exercise challenge
test (ECT). Before the ECT protocol commences, children are equipped with a
portable EMG amplifier. Before standard spirometry measurements, children are
asked to sit still for 45 seconds in order to perform EMG measurements.
Measurements will be repeated throughout the ECT protocol.
Study burden and risks
Participation in this study does not pose any additional risks to participants,
other than the risks involved with the scheduled ECT. Study related patient
burden is comprised of two sticky electrodes worn at the height of the
diaphragm and a bracelet around one of the arms. The portable amplifier is worn
on a belt. The study burden is negligible and no study related risks are
present. The study must be performed in children, as exercise induced
bronchoconstriction is a highly specific symptom in childhood asthma.
Koningsplein 1
Enschede 7512 KZ
NL
Koningsplein 1
Enschede 7512 KZ
NL
Listed location countries
Age
Inclusion criteria
exercise induced respiratory symptoms
referred for exercise challenge test at our center
ages between 7 and 18
Exclusion criteria
children and/or parents that do not speak dutch
ICD/pacemaker
co-morbid diseases other than asthma
premature birth (<37 weeks)
psychomotor retardation
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL73398.100.20 |